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Correlation of foveal microstructural changes with vision after anti–VEGF therapy in age-related macular degeneration

Poster Details

First Author: H.C.Kim SOUTH KOREA

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Abstract Details


To investigate the correlation of foveal microstructural changes with vision after intravitreal ranibizumab injection (IVR) in eye with choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).


Konkuk University Medical Center, Seoul Korea


We retrospectively studied 40 eyes of 40 patients with neovascular AMD who had no previous treatment history of AMD. All patients were treated with 3 monthly IVR (0.5 mg/0.05 mL) injections. One month after the third consecutive injection, best-corrected visual acuity (BCVA) was evaluated and the eyes were categorized into 2 groups according to the change in BCVA (good function group: BCVA improvement more than 0.3 logarithm of minimum angle of resolution (logMAR) ; poor function group: BCVA improvement less than 0.3 logMAR. Changes of foveal photoreceptor layer integrity, CNV size (diameter and thickness), central macular thickness (CMT), outer nuclear layer (ONL) thickness, and subretinal fluid in each group were also evaluated using spectral-domain optical coherence tomography.


The good function group is 20 eyes, and the poor function group is 20 eyes. No significant differences in baseline characteristics of variables including CNV type, initial BCVA, photoreceptor integrity, and CNV size were observed between the two groups. BCVA in the good function group was 0.30 ± 0.17 (logMAR) and that in the poor function group was 0.48 ± 0.40 (logMAR). Decreased disrupted length of photoreceptor layer (1,020.80 ± 974.60 um) and decreased CNV thickness (78.86 ± 50.78 um) were found in the good function group at the end of follow-up. However, no significant differences in changes of CNV diameter, CMT, ONL thickness, and resolution of subretinal fluid were observed between the two groups.


Restoration of foveal photoreceptor integrity and decreased CNV thickness are closely associated with visual improvement in neovascular AMD after treatment.

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