First Author: S.Demirel TURKEY
Co Author(s): F. Calıs E. Ozmert F. Batıoğlu 0 0 0 0 0 0 0 0 0
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To evaluate the effect of lutein supplementation on macular pigment optical density (MPOD) with color perimetry technique which is commercially available another psychophysical test in patients with age-related macular degeneration (AMD).
Prospective clinical study
46 eyes of 25 patients with dry AMD and 17 eyes of 17 healty control subjects with similar age and sex were included in this prospective study. Age, gender, family history, alcohol and tobacco usage, body mass index (BMI) and color of iris of the patients were recorded. The MPOD values were calculated before and after using lutein supplementation in dry AMD patients and at baseline and 6 months later in the healty control group.
Of the patients 24 were females and 18 were males. The mean age of the patients 67.27.93. In the study group, the ratio of tobacco usage and patients who were overweight were higher than control group. The mean MPOD value of the study group in before and after lutein supplementation were 3.361.84, 5.511.66, respectively. The increase of the MPOD value after lutein supplementation was statistically significant (p<0.01) while the value of MPOD (5.972.14) was stabil in the control group during 6-month follow-up.
The lower MPOD value of the study group than control group may be explained that the ratio of patients who were overweight and tobacco usage were higher than control group. With lutein suplementation during 6-month period, the increase of MPOD value was statistificially significant and it reached the value of the control group. There is growing evidence that suggests a relationship between levels of macular pigment and risk of age-related eye diseases, although a direct link has not yet been established. Accurate assessment of the amount of MP, expressed as MPOD, is necessary to investigate the role of carotenoids and their assumed protective functions. Color perimetry which is relatively new tecnique for MPOD measurement provides another mechanism for evaluating and comparing MPOD values.