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Immunological profile in patients with neovascular membrane associated with age-related macular degeneration

Session Details

Session Title: Quick Fire Free Paper 5

Session Date/Time: Sunday 14/09/2014 | 11:00-13:00

Paper Time: 12:35

Venue: Boulevard B

First Author: : M.Absalyamov RUSSIA

Co Author(s): :    M. Bikbov   N. Shevchuk           

Abstract Details

Purpose:

Investigate the change in the local immunological profile in patients with neovascular membrane associated with wet form of age-related macular degeneration.

Setting:

Ufa Eye Research Institute, Ufa, Russia.

Methods:

The level of cytokines in the humor of the anterior chamber in patients with wet form of age-related macular degeneration was determined. For determination of cytokines in wet form of age-related macular degeneration 22 patients were examined. Depending on the morphological features of the neovascular membrane the patients were divided into 3 groups: 1st - 8 people (8 eyes) - patients with classic neovascular membrane, 2nd - 7 people (7 eyes) - patients with mixed neovascular membrane; 3rd - 7 people (7 eyes) - patients with active fibrovascular membrane. Sampling of humor of anterior chamber was made during intravitreal injections by insulin syringe 30 G through a puncture in the cornea in paralimbal area. Interpretation of results was performed by using an automatic photometer «Multiscan» at a wavelength of 450 nm. The results were expressed in pg/ml. Normal level of these cytokines in the humor of anterior chamber for interleukin-1β -1,94 pg/ml; IL-6 -4,5 pg/ml for IL -18 -364 pg/ml; VEGF - 60 pg/ml, PEDF -3,08 pg/ml.

Results:

Level of IL-1β in the humor of the anterior chamber with classic neovascular membrane (group 1) averaged 1,422±0,23 pg/ml. When forming mixed CNV (group 2) - 2,667 ± 0,789 pg/ml (p1-2 <0.05). The level of IL-1β in patients of group 3 was the smallest - 1,327 ± 0,306 pg/ml. The level of IL-6 in group 1averaged 2,346 ± 0,756 pg/ml. The concentration of IL-6 in group 2 was 4,674 ± 1,87 pg/ml (p1-2 <0.05); in the third group - 1,79 ± 0,872 pg/ml. The concentration of IL-18 in the humor of anterior chamber (group 1) was 373,313 ± 93,452 pg/ml. Its concentrations was 320,874 ± 47,251 pg / mL and 337,483 ± 45,233 pg / ml in the 2nd and 3rd groups respectively. VEGF concentration in the humor of the anterior chamber in patients of group 1 was on average at 722,141 ± 48,479 pg/ml, in the group 2 - 353,37 ± 20,819 pg/ml (p1-2<0.05), in the 3rd group - an average of 120,216 ± 24,074 pg /ml (p1-2, p1-3 <0.05). Its concentrations was 0,549 ± 0,114 pg / mL and 0,531 ± 0,082 pg / ml in the 2nd and 3rd groups respectively.

Conclusions:

Change of cytokines level (IL-1β, IL-6, L-18, VEGF) in the humor of the anterior chamber of an eye shows correlation of the extent of process activity and location of the neovascular membrane.

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