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The analysis of risk factors for the radiation retinopathy following ruthenium brachytherapy of uveal melanoma

Session Details

Session Title: Quick Fire Free Paper 4

Session Date/Time: Sunday 14/09/2014 | 08:00-10:00

Paper Time: 09:30

Venue: Boulevard B

First Author: : I.Rospond-Kubiak POLAND

Co Author(s): :    J. Kociecki              

Abstract Details

Purpose:

to evaluate the risk factors for radiation retinopathy following the ruthenium brachytherapy of uveal melanoma

Setting:

retrospective case analysis

Methods:

The records of the patients treated due to uveal melanoma at the Department of Ophthalmology, Poznan University of Medical Sciences between 1991-2005 were analysed. The outcomes in terms of radiation retinopathy were correlated to the initial tumour characteristics using a StatSoft, Inc. (2011) STATISTICA, version 10.

Results:

64 patients (26 men, 38 women) had a mean age of 57,22 years. Mean largest basal diameter of the treated melanomas was 11,62 mm and mean thickness - 5,18 mm. Standard apical dose was 100 Gy. 38 patients had additional transpupillary thermotherapy, 8 (12,5 %) globes were enucleated, of wihich 4 due to neovascular glaucoma, 4 due to marginal recurrence. 25 patients died (39 %), 13 of metastatic disease (20 %). 25 patients (39 %) had the symptoms of radiation retinopathy. The risk factors for the radiation retinopathy were: largest basal diameter at presentation (p=0,00046) and tumour location close to the macula (p=0,0001). In most of the patients the symptoms of the radiation retinopathy appeared 4 years after the treatment.

Conclusions:

Radiation retinopathy was more likely to appear for the tumours with bigger largest basal diameter at presentation and situated close to the macula.

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