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Recurrent macular edema in retinal vein occlusion treated with intravitreal ranibizumab using a modified treat and extend regimen

Session Details

Session Title: Quick Fire Free Paper 4

Session Date/Time: Sunday 14/09/2014 | 08:00-10:00

Paper Time: 09:25

Venue: Boulevard B

First Author: : A.Ambresin SWITZERLAND

Co Author(s): :    A. Dirani   I. Mantel           

Abstract Details


To evaluate the stability of injection-recurrence interval of recurrent macular edema in retinal vein occlusion (RVO) when extending the interval between ranibizumab injection over one month.


Prospective case series of patients followed in the medical retina Unit, Jules Gonin University Eye Hospital, Lausanne for macular edema due to retinal vein occlusion.


After a minimum of five monthly ranibizumab injections, RVO patients with dry macula on SD-OCT were treated following a modified treat and extend regimen (mTER). This regimen first extended the interval by two weeks then fine adjusted by one week to maintain complete absence of fluid on SD OCT. The thereby defined individual interval was applied in a series of 3 injections, with new periodical mTER assessment thereafter.


Twelve patients with ME due to central vein occlusion were included. Preliminary analysis showed that BCVA (EDTRS letters) and qualitative SD OCT showed comparable results under monthly interval, after titration of individualised interval and when apply in a serie. The need for retreatment change over time did not vary significantly during the follow up.


A mTER regimen seems to be valuable to follow patients with recurrent macular edema due to RVO. The results suggest high stability of the individual need for retreatment.

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