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Effect of intracameral bevacizumab injection on corneal endothelial cells- in vivo evaluation

Session Details

Session Title: Quick Fire Free Paper 4

Session Date/Time: Sunday 14/09/2014 | 08:00-10:00

Paper Time: 09:15

Venue: Boulevard B

First Author: : M.Hosny EGYPT

Co Author(s): :    M. Zayed   A. Shalaby           

Abstract Details

Purpose:

We studied the effect of an intracameral Bevacizumab injection on the corneal endothelium and iris neovessels (INV).

Setting:

Department of Ophthalmology, Cairo University

Methods:

Twenty eyes of 20 patients were enrolled in this study. Group (A) included 10 eyes of 10 patients with an average age of 52.1 ± 13.17 years. Group (A) patients underwent intracameral Bevacizumab injections at a concentration of 1.25 mg/0.05 mL Group (B) served as a control group and included 10 eyes of 10 patients with an average age of 45.5 ± 9.8 years. Group (B) had panretinal laser photocoagulation. Gonioscopy, iris fluorescein angiography, pachymetry and specular microscopy were recorded preoperatively and postoperatively.

Results:

INVs started to regress clinically within the first 2 days after the injection and regressed completely by the end of the fourth week in Group (A). Reduction in INV leakage started one week after injection, and resolved in 8 eyes by the end of the fourth week in Group (A). In Group (B) INVs started to regress clinically in all 10 eyes 7 days after treatment and disappeared totally in 6 out of the 10 eyes after 3 weeks. Complete resolution of INV leakage occurred in 5 eyes after 3 weeks. The mean endothelial cell loss was 3.95% ± 6.78 in Group (A) and 3.18% ± 2.77 in Group (B) after 4 months.

Conclusions:

Intracameral Bevacizumab injection is effective for treatment of iris neovascularization and safe for corneal endothelial cells.

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