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In vivo evaluation of efficacy of systemic administration of oral slow release diclofenac sodium on intravitreal concentration

Session Details

Session Title: Quick Fire Free Paper 4

Session Date/Time: Sunday 14/09/2014 | 08:00-10:00

Paper Time: 08:50

Venue: Boulevard B

First Author: : M.Abrishami IRAN

Co Author(s): :    Y. Panahi   M. Naderi   K. Jadidi        

Abstract Details

Purpose:

To assess the efficacy of slow release 100 mg oral diclofenac sodium in penetrating and preparing intravitreal concentration in experimental model and comparing chemical injured and virgin eyes.

Setting:

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

Methods:

In this experimental double-masked clinical trial, 24 albino rabbits were included in the study. Right eyes of all rabbits were chemically injured by 1 N NaOH. One hour after chemical injury, 10 cc suspension gavage containing 100 mg slow release diclofenac sodium was administered in all cases. 2, 4, 6, 12, 24, 48 hours after gavage, vitreous samples were obtained in all cases. Intravitreal concentration of diclofenac sodium was evaluated in all samples using HPLC method.

Results:

In this study, we found that diclofenac sodium was entered the eye and the inflammation significantly increased the diclofenac concentration in the vitreous. After 6 hours, diclofenac was not significant in the vitreous and reduced below 1 μg/ml.

Conclusions:

Diclofenac is delivered to the inflamed eye more than healthy eye. It seems that by oral diclofenac, it is possible to make a significant intravitreal concentration. This study proposes an alternative intravitreal drug delivery system for intraocular inflammation control.

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