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Desegmentation of Ozurdex implant in vitreous cavity – report of two cases

Session Details

Session Title: Quick Fire Free Paper 3

Session Date/Time: Thursday 11/09/2014 | 14:30-16:00

Paper Time: 14:55

Venue: Boulevard D

First Author: : R.Agrawal UK

Co Author(s): :    P. Addison   G. Fernandez-Sanz   S. Bala        

Abstract Details

Purpose:

To report two cases of desegmentation or fracture of the Ozurdex implant observed immediately after routine intravitreal implantation for macular edema.

Setting:

Medical retina clinic for ozurdex implant.

Methods:

Retrospective chart review of two patients in the medical retina clinic receiving Ozurdex implant.

Results:

A rare complication of fracture of implant was noted immediately after the injection. No additional complication was noted in either of the patients. On follow up, the macular edema had resolved and there were no further complications. We shared our experience with the manufacturer and it was confirmed that, during the normal degradation process, the implant may become soft and break into pieces. Allergan shared their unpublished data on in vivo and in vitro drug release profile of one piece versus three pieces of implant which is presented in this free paper.

Conclusions:

With more and more microsurgical implantation procedures, clinicians should be well aware of these unusual albeit rare complications. Even though the desegmented implants do not appear to cause more intraocular complications compared with single piece implants, patients with defragmented implants should be followed up carefully to monitor for unexpected complications.

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