london euretina

This meeting has been awarded 20 CME credits

Security Notice

Please note that Kuoni are our only destination management company. Other venders indicating that are operating for the society should be ignored. We never use western union as a payment portal

Reticular pseudodrusen and the 5 year risk of progression for late AMD- a multimodal imaging approach

Session Details

Session Title: Quick Fire Free Paper 3

Session Date/Time: Thursday 11/09/2014 | 14:30-16:00

Paper Time: 14:50

Venue: Boulevard D

First Author: : J.Quadrado Gil PORTUGAL

Co Author(s): :    J. Marques   I. Lains   M. Costa   S. Nunes   M. Cachulo   R. Silva

Abstract Details


To determine whether reticular pseudodrusen (RPD) confer a long-term increased risk of progression to late age-related macular degeneration (AMD) in the second eye of patients with unilateral wet AMD


Ophthalmology Department, Centro Hospitalar e Universitário de Coimbra, Portugal. Associação para a Investigação Biomédica e Inovação em Luz e Imagem, Coimbra, Portugal.


Retrospective, observational, institutional study. Patients with wet AMD in one eye were included for evaluation of the risk of progression to late AMD in the second eye (study eye). A minimum follow-up of 5 years was required, unless progression to exudative AMD occurred first. Baseline images were analyzed, including fundus color photography (FCP), fundus auto-fluorescence (FAF), infra-red (IR) and red-free (RF) images. The images were graded using an innovative software (RetmarkerAMD®) Presence of RPD was considered when visible in at least one image mode. Baseline RPD profile and its impact in long-term AMD progression was evaluated.


63 patients (37 female) were included; with a mean age of 76.19 ± 6.63 years and mean follow-up of 66.03 ± 20.95 months. All patients had performed FCP, RF and FAF but only 33.33% (n=21) had IR available. When all cases were considered, the prevalence of RPD was 55.6% (n=35). The sub-group analysis of subjects with IR available revealed similar prevalence results (57.1%, n=12). The presence of RPD was more easily noted in IR and FAF (52.4% for both) than in FCP (15.8%). 65.1% (n=41) of the study eyes progressed to late-stage AMD, after a mean time of 30 ± 20.88 months. Time to progression was not significantly different between patients with and without RPD (30.64 and 31.77 months respectively, p=0.79). Of the study eyes which progressed, 82.9% (n=34) developed CNV and 17.1% (n=7) geographic atrophy (GA). After correcting for age and gender, the presence of RPD was significantly associated (OR=3.96, 95% CI [1.37–11.50], p=0.01) with development of late-stage AMD. This significance was maintained for CNV subtype (OR=3.31, 95% CI [1.16 – 9.49], p=0.026) but not for GA (OR=0.512, 95% CI[ 0.091 – 2.888], p=0.449).


Reticular pseudodrusen are associated with an increased risk of progression to late AMD in the second eye of patients with wet AMD. A multimodal approach using FAF and IR is mandatory for detecting RPD, underdiagnosed with FCP.

Back to previous
EURETINA, Temple House, Temple Road, Blackrock, Co Dublin. | Phone: 00353 1 2100092 | Fax: 00353 1 2091112 | Email:

Privacy policyHotel Terms and Conditions Cancellation policy