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Analysis of the effects of aflibercept in chronic neovascular age-related macular degeneration previously treated with bevacizumab or ranibizumab

Session Details

Session Title: Quick Fire Free Paper 3

Session Date/Time: Thursday 11/09/2014 | 14:30-16:00

Paper Time: 14:40

Venue: Boulevard D

First Author: : J.Pinheiro-Costa PORTUGAL

Co Author(s): :    J.M. Costa   J. Beato   P. Freitas-da-Costa   M.S. Falcão   F. Falcão-Reis   A.M. Carneiro

Abstract Details


To report the clinical outcomes of intravitreal aflibercept therapy in eyes with neovascular AMD switched from intravitreal bevacizumab or ranibizumab.


Department of Ophthalmology of Hospital de São João, Porto, Portugal.


A retrospective review of 86 eyes treated in a 1+PRN regimen in a clinical setting with bevacizumab or ranibizumab that were switched to aflibercept. Aflibercept was used in patients considered refractory to bevacizumab (persistent exudation despite consecutive injections) – group 1, and in patients on therapy with ranibizumab due to an institutional policy decision (controlled with exudation suppressed, but requiring frequent injections) – group 2. Changes in best-corrected visual acuity (BCVA), anatomic response with the switch, central retinal thickness (CRT) and frequency of injections were compared.


Eighty six eyes of 69 patients were analyzed; 39 eyes in group 1 and 47 in group 2. Mean follow-up time was 18 months prior to the switch and 5.9 months with aflibercept. Visual acuity showed stability with therapeutic switch in both groups (group1: 58.2 and 58.4, p=0.900; group2: 55.5 and 55.1, p=0.725) and the mean number of injections per month was significantly lower (0.753 vs 0.649, p=0.030). With the switch to aflibercept, 89.5% of patients showed anatomic improvement with reduction of intra and/or subretinal fluid and both groups presented significant improvement in CRT (Group 1, 68.5 µm (p=0.040); Group 2, 85.0 µm (p < 0.001)).


Switching patients with neovascular AMD from bevacizumab or ranibizumab to aflibercept results in anatomical improvement and stabilized vision, while allowing injection intervals to be extended.

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