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Analysis of drusen volume and area changes

Session Details

Session Title: Quick Fire Free Paper 3

Session Date/Time: Thursday 11/09/2014 | 14:30-16:00

Paper Time: 14:30

Venue: Boulevard D

First Author: : S.Y.Yu SOUTH KOREA

Co Author(s): :    H.W. Kwak              

Abstract Details

Purpose:

To quantitate the drusen area and volume changes using the automated RPE elevation map algorithm of SD-OCT and to determine the risk factor of drusen progression

Setting:

The study was carried out in Kyung Hee University Hospital, Seoul, Korea.

Methods:

70 eyes of 52 patients with patients with drusen on fundus exam included and follow-up for at least 12 months. The patients were imaged by Cirrus SD-OCT (Carl Zeiss Meditec, Doublin, CA, USA). Drusen area and volume were measured within circular regions centered at the fovea having diameters of 3 and 5 mm and regions using the automated RPE elevation map algorithm.

Results:

We analyzed 70 eyes with followed for 12 month, 60 eyes followed for 24 months, 48 eyes followed for 36 months. On average, drusen area and volume increased over time but there were no significant changes until 12 month. After 24 months, area and volume of drusen increased statistically significantly (p <0.05). At 24 months, drusen volume increased in 56.1% of eyes and decreased in 17.0%. At 36 months, drusen volume increased in 58.6% of eyes and decreased in 20.7%. Age and wet AMD in fellow eye significantly increase the risk of drusen progression (odd ratio=1.26, p=0.00, odd ratio=12.5 ,p=0.49, respectively).

Conclusions:

Drusen has shown a tendency to increase with the follow-up period. Quantitative changes in drusen volume and area over time using SD-OCT imaging provides a useful strategy for following drusen progression. But, it seems that analysis of the drusen require long-term follow up due to a few changes of the drusen area and volume

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