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Intra-silicone oil injection of methotrexate at the end of retinal reattachment surgery for severe proliferative vitreoretinopathy

Session Details

Session Title: Quick Fire Free Paper 2

Session Date/Time: Thursday 11/09/2014 | 11:00-12:30

Paper Time: 12:15

Venue: Boulevard D

First Author: : K.Ghasemi Falavarjani IRAN

Co Author(s): :    M. Modarres   M.M Parvaresh   M. Hashemi   M. Naseripour   A. Hadavand Khani  

Abstract Details


To evaluate the role of intrasilicone injection of methotrexate at the end of retinal reattachment surgery for rhegmatogenous retinal detachment (RRD) associated with severe proliferative vitreoretinopathy (PVR) for prevention of postoperative PVR and compare the results with those without intrasilicone injection.


Rassoul Akram Hospital, Iran University of Medical Sciences


In this prospective comparative interventional study, eyes with RRD with grade C PVR underwent standard parsplana vitrectomy and retinal reattachment surgery. In case group, 200 µg of methotrexate was injected into the silicone oil at the end of surgery. The rate of retinal redetachment associated with PVR was assessed.


Forty eyes of 40 patients (20 cases and 20 controls) with a mean age of 50.6±19.3 years were studied. The two groups were matched for baseline characteristics. Retinal redetachment with PVR occurred in 3 (15%) and 5 (25%) eyes in case and control groups, respectively (P=0.1). At final visit, visual acuity was similar between the two groups (1.6±0.8 and 1.6±0.6, respectively, P=0.8).


Intra-silicone injection of methotrexate at the end of vitrectomy for RRD with severe PVR, reduces but does not eliminate the risk of postoperative PVR.

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