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The effect of prophylactic nepafenac 0,1% eye drops on macular changes after phacoemulsification for non-proliferative diabetic retinopathy patients in Indonesia- a preliminary report

Session Details

Session Title: Quick Fire Free Paper 2

Session Date/Time: Thursday 11/09/2014 | 11:00-12:30

Paper Time: 12:00

Venue: Boulevard D

First Author: : S.Soedarman INDONESIA

Co Author(s): :    A. Djatikusumo   S. Widyawati   A. Setiawati        

Abstract Details

Purpose:

To evaluate the effect of prophylactic nepafenac eye drops on macular thickness changes after phacoemulsification surgery in mild to moderate NPDR patients

Setting:

KIrana Eye Hospital,RSCM, Jakarta, Indonesia

Methods:

This study is an open label randomized clinical trial. Thirty-six subjects who met the inclusion criteria underwent phacoemulsification. One group (18 subjects) were given nepafenac 0,1% eye drops and the rest were given placebo; both products were used 3 days before phacoemulsification until 14 days after phacoemulsification. Foveal thickness and total macular volume were measured by SD-OCT before surgery and the fourth week after phacoemulsification. Best corrected visual acuity (BCVA) and degree of inflammation in the anterior chamber were also being assessed.

Results:

There was a statistically significant increase foveal thickness in the placebo group 4 weeks after phacoemulsification (paired t-test, p=0,022). In the nepafenac group there was no significant changes in the foveal thickness 4 weeks after phacoemulsification (paired t-test, p = 0,538). One patient in the placebo group had CME. There was an increased in total macular volume, which were statistically significant in both groups (paired t-test, p<0,05) although not significantly different between the two groups (unpaired t-test, p= 0,621). Clinically, percentage degree of inflammation in anterior chamber in placebo group was higher than nepafenac group (38,9% : 5,6%) but not significantly different between 2 groups (Kolmogorov-Smirnov test, p=0,27). Nepafenac group achieved clinically better BCVA than the placebo group 4 weeks after phacoemulsification, although statistically there was no significant difference between two groups (unpaired t-test, p=0,991).

Conclusions:

Nepafenac 0,1% eye drops could prevent foveal thickening 4 weeks after phacoemulsification in mild to moderate NPDR patients. Clinically, nepafenac 0,1% eye drops could decrease the risk of inflammation in the anterior chamber, risk of CME, and vision deterioration although did not reach statistically significant.

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