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Short-term results of intravitreal ranibizumab injection in eyes with diabetic macular edema

Session Details

Session Title: Quick Fire Free Paper 1

Session Date/Time: Thursday 11/09/2014 | 08:00-10:00

Paper Time: 08:15

Venue: Boulevard D

First Author: : K.Nabawi EGYPT

Co Author(s): :    A. Sharaf   H. Sowelam           

Abstract Details

Purpose:

study of 1 week and 1 month spectral domain optical coherence tomography(SD-OCT) central macular thickness (CMT) and visual acuity (VA) changes post injection of intravitreal ranibizumab in eyes with diabetic macular edema (DME).

Setting:

71 eyes of 62 patients recruited at the outpatient ophthalmology clinic at Alexandria university hospital.

Methods:

history taking, and ophthalmic examination (including fundus biomicroscopy, SD-OCT, and VA) were done at presentation, 1 week, and 1 month post intravitreal ranibizumab injection (0.5mg/0.05ml). Eyes were subtyped according to the type of macular edema (spongiform, cystic, and subretinal fluid SRF). Also, the presence/absence of epiretinal membrane (ERM) was recorded.

Results:

Eyes with all types of retinal edema showed significant reduction of CMT at 1 week and 1 month post injection. Those with SRF were the most significant (477M-447M-386M), cystic (439M-358M-332M), then spongiform (298M-285M-272M). Eyes with ERM showed non-significant decrease in CMT (381M-358M-312M). VA improvement was most significant in eyes with cystic and SRF at 1 month post injection. Yet, eyes with spongiform edema and ERM showed non-significant VA gain.

Conclusions:

patients with DME can be counseled before intravitreal ranibizumab injection depending on their subtype of macular edema for short-term improvement in their VA and CMT. Eyes with cystic edema and SRF gain the most benefit as compared to eyes with spongiform edema and those with ERM.

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