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Identifying progression of retinal disease in eyes with mild NPDR in diabetes type 2 using non-invasive procedures

Session Details

Session Title: Imaging III

Session Date/Time: Saturday 13/09/2014 | 14:30-16:00

Paper Time: 15:26

Venue: Boulevard C

First Author: : I.Pires PORTUGAL

Co Author(s): :                  

Abstract Details


Purpose To identify eyes of patients with diabetes type 2 that show progression of retinal disease within a one-year period of follow-up using non-invasive techniques.


1. AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal 2. Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal 3. – European Vision Institute Clinical Research Network, Coimbra, Portugal


Three hundred seventy four (374) type-2 diabetic patients with mild nonproliferative diabetic retinopathy (NPDR) (ETDRS levels 20 or 35) were included in a 12-month observational and prospective study to identify retinopathy progression. Patients were included in 19 clinical sites from the European Vision Institute Clinical Research Network ( Four visits were scheduled at months 0, 3, 6 and 12 with the following examinations: color fundus photography (CFP), spectral domain optical coherence tomography (SD-OCT) and blood tests. ETDRS severity level in the first and last visits was assessed centrally by the Coimbra Ophthalmology Reading Center (CORC). SD-OCT was used to measure retinal thickness (RT) and ganglion cell layer thickness. One eye per patient was selected as the Study Eye.


374 patients/eyes with mild NPDR were included (65.0% males and 35.0% females) with ages ranging from 35 to 82 years (18.4% graded as level 20 and 81.6% as level 35, ETDRS severity scale). Mean BCVA was 84.9±6.3 ETDRS letters. Mean HbA1C was 7.8±1.5% and the systolic and diastolic blood pressure was respectively of 137.6±16.6 and 77.4±10.0 mmHg. 328 eyes/patients completed the study (325 completed the 12-month visit). The mean central RT at baseline was 264.9±21.9 µm (Cirrus SD-OCT). At the 6-month visit (336 eyes/patients), 18 eyes (5.4%) showed a central subfield RT decrease of 5% or more, whereas 30 eyes (8.9%) showed a central subfield RT increase higher than 5%. Changes in the paracentral subfields and central subfield were also analysed as well as their rate of change during the one year period of follow-up.


Different eyes/patients with diabetes type 2 and mild NPDR show different changes in RT over the twelve month follow-up period. The perifoveal RT values are directly related with central retinal thickness values.

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