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Identifying progression of retinal disease in eyes with mild NPDR in diabetes type 2 using non-invasive procedures

Session Details

Session Title: Imaging III

Session Date/Time: Saturday 13/09/2014 | 14:30-16:00

Paper Time: 15:26

Venue: Boulevard C

First Author: : I.Pires PORTUGAL

Co Author(s): :                  

Abstract Details

Purpose:

Purpose To identify eyes of patients with diabetes type 2 that show progression of retinal disease within a one-year period of follow-up using non-invasive techniques.

Setting:

1. AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal 2. Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal 3. EVICR.net – European Vision Institute Clinical Research Network, Coimbra, Portugal

Methods:

Three hundred seventy four (374) type-2 diabetic patients with mild nonproliferative diabetic retinopathy (NPDR) (ETDRS levels 20 or 35) were included in a 12-month observational and prospective study to identify retinopathy progression. Patients were included in 19 clinical sites from the European Vision Institute Clinical Research Network (EVICR.net). Four visits were scheduled at months 0, 3, 6 and 12 with the following examinations: color fundus photography (CFP), spectral domain optical coherence tomography (SD-OCT) and blood tests. ETDRS severity level in the first and last visits was assessed centrally by the Coimbra Ophthalmology Reading Center (CORC). SD-OCT was used to measure retinal thickness (RT) and ganglion cell layer thickness. One eye per patient was selected as the Study Eye.

Results:

374 patients/eyes with mild NPDR were included (65.0% males and 35.0% females) with ages ranging from 35 to 82 years (18.4% graded as level 20 and 81.6% as level 35, ETDRS severity scale). Mean BCVA was 84.9±6.3 ETDRS letters. Mean HbA1C was 7.8±1.5% and the systolic and diastolic blood pressure was respectively of 137.6±16.6 and 77.4±10.0 mmHg. 328 eyes/patients completed the study (325 completed the 12-month visit). The mean central RT at baseline was 264.9±21.9 µm (Cirrus SD-OCT). At the 6-month visit (336 eyes/patients), 18 eyes (5.4%) showed a central subfield RT decrease of 5% or more, whereas 30 eyes (8.9%) showed a central subfield RT increase higher than 5%. Changes in the paracentral subfields and central subfield were also analysed as well as their rate of change during the one year period of follow-up.

Conclusions:

Different eyes/patients with diabetes type 2 and mild NPDR show different changes in RT over the twelve month follow-up period. The perifoveal RT values are directly related with central retinal thickness values.

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