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The role of antibiotics in the prevention of post-intravitreal anti-VEGF endophthalmitis- primum non nocere!

Session Details

Session Title: New Drug Treatment

Session Date/Time: Saturday 13/09/2014 | 14:30-16:30

Paper Time: 16:14

Venue: Boulevard F

First Author: : A.Grzybowski POLAND

Co Author(s): :    J. Pieczynski              

Abstract Details


To analyse the rate of post intravitreal injection (ivi) endophtalmitis and its connections with use or lack of topical antibiotic prophylaxis and development of bacterial resistance after topical prophylactic use of antibiotics.


Globally antibiotics are overused in different fields of medicine, what causes antibiotic resistance. This may lead to loss of activity of major antibiotics and inability to use them in future, increase in multidrug resistance and increase in infections caused by antibiotic-resistant bacteria and increase in health care costs.


We analysed PubMed platform from 01.01.2003 till 01.02.2014 to search articles presenting the relation of post ivi endophtalmitis with the use or no use of topical antibiotic, and studies showing development of bacterial resistance and changing in conjunctival flora after repeated topical use of antibiotics.


We divided search results into three groups: 1. endophtalmitis and ivi (17 articles); 2. bacteria resistance and ivi (6 articles); 3. conjunctival bacteria flora and ivi (2 articles).


There is no evidence that the use of topical antibiotics before ivi protect against endophthalmitis. Repeated use of antibiotics changes the conjunctival flora and increases the rate of resistance of CNS to antibiotics. We should be aware that using antibiotics without clear benefit, might be harmful.

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