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Peculiarities of structural changes of the retina in streptozotocin-induced diabetic rats in different terms (2 weeks and 1 month)

Session Details

Session Title: Vascular Diseases and Diabetic Retinopathy III

Session Date/Time: Friday 12/09/2014 | 16:30-18:00

Paper Time: 17:26

Venue: Boulevard D

First Author: : T.Pilkevich UKRAINE

Co Author(s): :    N. Pasyechnikova   V. Naumenko   V. Vit   E. Ivanitskaya     

Abstract Details


To study the influence of erythropoietin (Epo) on structural changes of the retina in streptozotocin-induced diabetic rats.


SI “The Filatov Institute of Eye Diseases and Tissue Therapy of NAMS of Ukraine”, Odessa, Ukraine


50 rats (100 eyes) were included in the experiment. All rats were divided into 3 groups: 1st – 10 intact rats, 2nd – 20 rats with DM, 3rd – 20 rats with DM receiving Epo. Epo was administered in dosage of 6 units per 100 g of body weight. Animals were euthanized at 2 weeks and 1 month. Enucleated eyes were studied by a histological method.


After 2 weeks structural changes of the retina were noted in 8 of 10 rats of 2nd group: focal edema of the inner plexiform layer, uneven distribution of ganglion cells, focal retinal thinning, gliosis near vessels, and signs of destruction of the vascular wall. After 1 month all layers were affected, swelling and vacuolar degeneration of ganglion cells were increased. Retinal vessels changes: unevenly thickened wall of the arteries, somewhere destroyed, endothelial cells unevenly distributed, and focal round cell proliferates determined around blood vessels. Venous vessels were tortuous, with perivascular edema. In 3rd group only 2 of 10 animals had retinal changes after 2 weeks: mild focal edema of inner retinal layers. After 1 month changes were the same at 6 rats. There were no changes of vessels in inner retinal layers.


Dystrophic structural changes in the retina may be associated with both direct toxic effects of streptozotocin and blood circulatory problems. Structural changes after 1 month are harder then after 2 weeks. Erythropoietin has obvious protective action on the retina: there was only mild edema of ganglion cells. Retinal histoarchitecture was normal. We suggest that less pronounced retinal changes may be result of blood circulation improvement or direct neuroprotective effect of erythropoietin.

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