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Retina examination with examination with curcumin for the diagnosis of Alzheimer's disease

Session Details

Session Title: Imaging II

Session Date/Time: Friday 12/09/2014 | 16:30-18:00

Paper Time: 17:34

Venue: Boulevard C

First Author: : U.AKayabasi TURKEY

Co Author(s): :    R.C. Sergott              

Abstract Details

Purpose:

To demonstrate Alzheimer’s (AD) plaques in retina .It has been suggested that Beta amyloid starts to accumulate in the retina evenbefore it affects the brain. Some studies even showed amyloid depositions in regions close to age related macular degeneration(AMD) lesions.

Setting:

All the patients were examined with fundus autofluorescein and optical coherence tomography at the eye hospital. Then, they were sent for brain PET- CT examination.

Methods:

We examined 25 patients with a family history of AD and/or mild cognitive defects. All the patients were given oral curcumin for three days before the exam. In the patients in whom we found hyper or hypofluorescent lesions on fundus autofluorescence (FAF), optical coherence tomography (OCT) was performed through these regions to reveal depositions in the ganglion and nerve fiber layers. None of thepatients had retinal vascular disease due to hypertension or diabetes mellitus ; only drusen like spots- dots were noticed in different parts of the retina. Defects on RPE were not taken into consideration so that AMD lesions would be separated from the other accumulations

Results:

In 22 patiens, we were able to find abnormal deposits in the ganglion and nerve fiber layers. We believe that these plaque- like lesions are related to neuro- degenerative disease (AD). Curcumin made the spots brighter All the patients had positive brain PET-CT findings.

Conclusions:

We stress that all the middle- aged patients who have family history of AD should have thorough medical examinations and retina investigation may be a part of the exam. This is the first study in which AD plaques were shown in the retinas of alive AD patients with FDA approved devices.

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