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Non-invasive retinal and choroidal microangiography using 1060nm dual-beam doppler optical coherence tomography in patients with choroidal neovascularization, proliferative diabetic retinopathy and branch retinal vein occlusion

Session Details

Session Title: Imaging II

Session Date/Time: Friday 12/09/2014 | 16:30-18:00

Paper Time: 17:18

Venue: Boulevard C

First Author: : C.Mitsch AUSTRIA

Co Author(s): :    R. Leitgeb   U. Schmidt-Erfurth           

Abstract Details

Purpose:

To contrast the microvasculature network of the posterior segment in patients with distinct retinal vascular pathologies such as proliferative diabetic retinopathy, retinal vessel occlusion and choroidal neovascularization secondary to age-related macular degeneration using a bidirectional dual beam Doppler 200 MHz high-speed Swept Source Optical Coherence Tomography (OCT) System at 1060nm.

Setting:

Department of Ophthalmology and Optometrics, Center for Biomedical Engineering and Physics. Medical University of Vienna

Methods:

Patients were examined during a single-visit examination performing traditional fluorescein and indocyanin angiography, Spectral Domain OCT retinal imaging and Doppler-OCT imaging. We use a bidirectional dual beam platform with flexible aligning of the incidence plane working at 200 MHz allowing vessel contrasting to assess the vascular network branching and integrity and the reconstruction of the true flow velocity in the range of 5 to 500mm/s.

Results:

Highly sensitive flow contrasting has been performed at selected pathological location in patients with diabetic retinopathy, retinal vein occlusion and choroidal neovascularization. It reveals specific alterations of the vascular network, like signs of vessel density loss, and irregular vessel proliferation, showing correlation with traditional angiography.

Conclusions:

We apply a 200MHz dual beam bidirectional Doppler-OCT system for non-invasive 3D microangiography of the posterior segment and to accurately quantify blood flow dynamics in the human eye. We present measurements performed in patients with distinct retinal vascular pathologies such as diabetic retinopathy, retinal vein occlusion and choroidal neovascularization. The motion artifact stable and accurate flow quantification and visualization may therefore lead ultimately to a better understanding and an enhanced early diagnosis of retinal vascular diseases.

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