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Fluorescence lifetime characteristics in central serous chorioretinopathy

Session Details

Session Title: Imaging II

Session Date/Time: Friday 12/09/2014 | 16:30-18:00

Paper Time: 16:54

Venue: Boulevard C

First Author: : L.Berger SWITZERLAND

Co Author(s): :    C. Dysly   J. Kowal   S. Wolf   M. Zinkernagel     

Abstract Details

Purpose:

Central serous chorioretinopathy (CSCR) is an idiopathic disorder characterised by serous detachment of the neurosensory retina, usually in the macular area that leads to loss of vision and metamorphopsia. Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) is a novel imaging method that allows non-invasive measurements of fluorescence lifetimes in vivo in the retina. Fluorescence lifetime characteristics are influenced by various layers of the retina and probably also by the underlying choroid.

Setting:

Subjects were recruited from the retinal clinic at the Department of Ophthalmology at the University Hospital of Berne.

Methods:

Fluorescence lifetime measurements of 7 patients (age 50,7± 0.522, mean±SEM) with chronic CSCR and serous retinal detachment detected by Spectralis – OCT and 12 probands (age 46 years ± 2.35) with no ophthalmological or systemic diseases were performed using a Fluorescence Lifetime Imaging Ophthalmoscope (FLIO). Fluorescence decay times were measured in a short wavelength channel (498 – 560 nm) and in a long wavelength channel (560 – 720 nm). Short fluorescence lifetimes (tau 1), long fluorescence lifetimes (tau 2) and mean fluorescence lifetimes (tau mean) in each channel were calculated for each acquired pixel within the retina by time-correlated single photon counting. The acquired data were analysed using the customised software “FLIOreader” (ARTORG Center Berne). For comparison purposes an ETDRS grid was used to average fluorescence lifetimes for different retinal areas. Fluorescence lifetimes of each ETDRS area in CSCR were compared with the corresponding area in healthy, age matched controls.

Results:

For the short wave length channel (498 – 560 nm) average mean fluorescence lifetimes were significantly shorter in retinal areas with serous retinal detachment versus healthy controls (p<0.05). For the long wave length channel (560 – 720 nm) the average mean fluorescence lifetimes in patients with CSCRwas significantly shorter than in healthy age matched controls (p<0.05).

Conclusions:

Fluorescence lifetime imaging of the retina is a new technique that may serve as a tool to diagnose and characterise retinal diseases and may be useful for early detection of metabolic changes of the retina. Fluorescence lifetime imaging in CSCR may be useful for monitoring of disease progression. Additionally, the distinct fluorescence lifetime characteristics seen in CSCR may help to gain a better understanding of the factors influencing fluorescence lifetimes of the retina.

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