Session Title: Imaging I
Session Date/Time: Friday 12/09/2014 | 11:00-13:00
Paper Time: 11:08
Venue: Boulevard D
First Author: : K.Eibenberger AUSTRIA
Co Author(s): : B. Gerendas P. Roberts W. Bühl M. Kundi U. Schmidt-Erfurth S. Sacu
To evaluate the morphological characteristics in different modalities as predictive factors for chronicity in central serous chorioretinopathy (CSC). The modalities were spectral-domain optical coherence tomography (SD-OCT), infrared and near-infrared autofluorescence and color fundus photography (CF).
In this prospective observational study, 52eyes of 51patients with CSC were recruited from the outpatient clinic of the Department of Ophthalmology, Vienna General Hospital. CSC was diagnosed based on clinical examination, SD-OCT, fluorescein- and indocyanine green-angiography (FA&ICGA). All images underwent standardized evaluation by certified graders of the Vienna Reading Center.
Patients suffering from an acute episode of CSC were observed until recovery. An independent expert consortium of retinologists divided the cases into two groups at baseline from angiography: acute and chronic CSC, whereas chronic was considered “recurrent” CSC. The results of the non-invasive baseline examinations were analyzed and eight morphological abnormalities were determined by another independent expert consortium of retinologists as possible predictors. These morphological characteristics were: number (1) and area (2) of pigment epithelial detachments (PEDs) and number (3), total height (4), shape (5) and area (6) of subretinal fluid deposits in SD-OCT; pigment epithelial irregularities in CF (7); increased area of hyperautofluorescence in AF (8). The predictors were correlated using Wald-test the experts groups’.
Mean age of the patients was 43.4±9.7 years (range: 26 to 68). The greater the area of PEDs (2) (p=0.022), the lower the total height of SRF (4) (p=0,033), the larger the area of SRF (6) (p=0.043) and the more hyperautofluorescence (8) (p=0,035), the greater the risk of CSC recurrence. (1), (3), (5), (7) do not significantly correlate to recurrence.
Some morphological characteristics correlate to recurrence rate of CSC. Large area of PED and SRF and low SRF height in SD-OCT as well as high rate of hyperautofluorescence in AF provide evidence of recurrent CSC and might be an indicator for early PDT treatment whereas small area of PED and SRF and high SRF as well as low rate of hyperautofluorescence in AF may indicate a first episode of CSC and longer observance time.