london euretina

This meeting has been awarded 20 CME credits

Security Notice

Please note that Kuoni are our only destination management company. Other venders indicating that are operating for the society should be ignored. We never use western union as a payment portal

5 year results of combined treatment for polypoidal choroidal vasculopathy- verteporfin PDT and intravitreal anti-VEGF

Session Details

Session Title: AMD II

Session Date/Time: Friday 12/09/2014 | 08:00-10:00

Paper Time: 09:12

Venue: Boulevard D

First Author: : H.W.Kwak SOUTH KOREA

Co Author(s): :    S.Y. Yu              

Abstract Details


To evaluate the 5-year efficacy of photodynamic therapy (PDT) combined with intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) in patients with polypoidal choroidal vasculopathy (PCV)


The study was carried out in Kyung Hee University Hospital, Seoul, Korea.


Twenty-seven eyes of 43 patients with symptomatic PCV in treatment naïve eyes followed up for ≥60 months after PDT and anti-VEGF combination therapy were retrospectively reviewed. The patients received intravitreal anti-VEGF (1.25 mg bevacizumab or 0.5 mg ranibizumab) within 7 days after PDT. All clinical data, including baseline characteristics; imaging data from fluorescein angiography, indocyanine green angiography, and optical coherence tomography; presence of recurrence; and best-corrected visual acuity (BCVA) were investigated.


The mean baseline BCVA was 0.63±0.44 logMAR, 0.36±0.29 logMAR at 12 months (p=0.001 vs. baseline) and 0.61±0.49 at 60 months (p=0.848). On the final evaluation at 60 months, the mean BCVA was improved in 16 eyes (37.2%), stable in 11 eyes (25.6%), and decreased in 16 eyes (37.2%). Mean BCVA was significantly improved up to 12 months and then improvement slowly decreased over 60 months. Significant improvement maintained until 36 months (p=0.05). The mean CFT was 344.3 ± 114.8 at baseline and significantly decreased to 229.3 ± 60.9 at 12 months and the final CFT at 60 months was 231.3 ± 63.4. PDT was administered 1.79 ± 1.28 times and anti-VEGF injected 8.28±6.89 times over the 60-month period. Multiple regression analysis showed old age (p = 0.021), large PDT size (p = 0.006) were significantly negatively associated with BCVA change at final visit


Significant visual improvement by combined PDT and anti-VEGF injection was maintained up to the third year of initial treatment; however, utmost improvement decreased after the first year. After 60 months, 62.8 % of PCV patients showed stable or improved BCVA. The old age and large PDT size were significantly associated with long-term visual outcome.

Back to previous
EURETINA, Temple House, Temple Road, Blackrock, Co Dublin. | Phone: 00353 1 2100092 | Fax: 00353 1 2091112 | Email:

Privacy policyHotel Terms and Conditions Cancellation policy