london euretina

This meeting has been awarded 20 CME credits

Security Notice

Please note that Kuoni are our only destination management company. Other venders indicating that are operating for the society should be ignored. We never use western union as a payment portal

How many injections of ranibizumab are necessary in the first year of wet AMD treatment? A meta-analysis

Session Details

Session Title: AMD II

Session Date/Time: Friday 12/09/2014 | 08:00-10:00

Paper Time: 08:24

Venue: Boulevard D

First Author: : H.Gerding SWITZERLAND

Co Author(s): :                  

Abstract Details


Although ranibizumab is widely used in age-related macular degeneration there is so far no systematic analysis available on the relation between injection frequency and functional efficacy within the first 12 months of treatment.


Meta-analysis on available Medline literature.


47 relevant clinical studies (54 case series) could be identified covering 11.706 treated eyes. Non-linear and linear regression was calculated for the relation between treatment frequency and functional outcome (average gain in visual acuity, % of eyes losing less than 15 letters of visual acuity, % of eyes gaining ≥15 letters) within the first year of care.


Mean improvement of average visual gain was +4.9 +/- 3.6 (mean +/- 1 standard deviation) letters (case-weighted: 3.3 letters). The average number of ranibizumab injections until month 12 was 6.3 +/-2.0 (case-weighted: 5.9). 92.4 +/- 3.9 % of eyes (case-weighted: 91.9 %) lost less than three lines of visual acuity and 24.5 +/- 8.2 % (case-weighted: 23.3) gained more than 3 lines within the first year. Analysis of the relation between the number of injections and functional improvement indicated best fit for non-linear equations. A nearly stepwise improvement of functional gain occurred between 6.8 and 7.2 injections/year. A saturation effect of treatment occurred beyond this level of injection frequency.


The results of this meta-analysis clearly indicate a non-linear relation between the number of injections and functional gain of ranibizumab within the first 12 months of treatment. Treatment saturation seems to occur at a treatment frequency >7.2 injections within the first 12 months.

Back to previous
EURETINA, Temple House, Temple Road, Blackrock, Co Dublin. | Phone: 00353 1 2100092 | Fax: 00353 1 2091112 | Email:

Privacy policyHotel Terms and Conditions Cancellation policy