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Prevalence of age-related macular degeneration in Portugal- the Coimbra eye study

Session Details

Session Title: AMD II

Session Date/Time: Friday 12/09/2014 | 08:00-10:00

Paper Time: 08:00

Venue: Boulevard D

First Author: : M.Cachulo PORTUGAL

Co Author(s): :    I. Laíns   C. Lobo   J. Figueira   M. Costa   S. Nunes   R. Silva

Abstract Details


To evaluate the prevalence of early and late age-related macular degeneration (AMD) in two Portuguese population-based samples.


Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal.


Cross-sectional population-based study. Patients older than 55 years old of two Portuguese primary health-care units were invited to participate: one from a coastal village of the center of Portugal and another from the inner region of the country. Responders underwent complete ophthalmologic examination and fundus imaging. Early and late age-related macular degeneration were defined according to the International Age Related Macular Epidemiological Study Group Classification. An innovative semi-automated software (RetmarkerAMD Research, Critical Health, SA, Portugal) was used for grading. The age and gender adjusted prevalences of early and late AMD were determined.


Of the 8430 eligible subjects, 6025 underwent study procedures (71.5% response rate) and 5998 were included in the analysis, with a mean age of 68.68 ± 8.7 years. The overall prevalence of early AMD was 18.88%. Late AMD was present in 1.11% of the study population, with neovascular and geographic atrophic subtypes accounting for 0.47% and 0.65% of individuals, respectively. The highest prevalence of advanced AMD was among those aged ≥75 years. Over 80% of the study population showed no features of age-related maculopathy or only drusen <63 µm.


To our knowledge, this was the first AMD epidemiologic study performed in a Portuguese population. The early forms of the disease presented similar prevalence of other large-scale population-based cohorts, but late AMD, namely the neovascular form, was less frequent than previously reported.

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