london euretina

This meeting has been awarded 20 CME credits

Security Notice

Please note that Kuoni are our only destination management company. Other venders indicating that are operating for the society should be ignored. We never use western union as a payment portal

Response of the retinal pigment epithelium (RPE) to antiangiogenic therapy in neovascular age-related macular degeneration (AMD)

Session Details

Session Title: AMD I

Session Date/Time: Friday 12/09/2014 | 08:00-10:00

Paper Time: 08:16

Venue: Boulevard C

First Author: : C.Schütze AUSTRIA

Co Author(s): :    M. Wedl   B. Baumann   M. Pircher   C.K. Hitzenberger   U. Schmidt-Erfurth  

Abstract Details

Purpose:

To identify the biologic response of the retinal pigment epithelium (RPE) to antiangiogenic therapy for neovascular age-related macular degeneration (AMD) using selective RPE imaging by polarization-sensitive optical coherence tomography (PS-OCT).

Setting:

Medical University of Vienna

Methods:

Thirty patients (31 eyes) with treatment-naïve neovascular AMD treated with intravitreal Ranibizumab were included in this study. Patients were examined by SD- (spectral domain) and PS-OCT (capable of specifically detecting the RPE and associated changes) prior to anti-VEGF therapy (baseline), 1, 3, 6, 12 and 24 months postoperatively, focusing on RPE characteristics in PS-OCT. Geographic atrophy (GA) dimensions were evaluated using a semi-automated segmentation algorithm in PS-OCT. SD- and PS-OCT results were compared.

Results:

Specific RPE changes were evident in PS-OCT during follow-up including RPE loss: RPE porosity, focal RPE-atrophy, GA, RPE-thinning; and RPE migration: accumulations of depolarizing material at the RPE level and ectopic depolarizing material in outer retinal layers. GA dimensions in PS-OCT were detected in 19 patients at month 24 with a mean area of 1.10mm2 (±1.09). PS-OCT unambiguously identified the RPE layer while conventional intensity-based SD-OCT failed to detect RPE changes.

Conclusions:

Characteristic and dynamic changes of the RPE layer were shown in patients undergoing antiangiogenic therapy for neovascular AMD using RPE-specific imaging by PS-OCT. RPE loss and RPE migration was identified. RPE atrophy was generally increasing and GA progression was evident following 24 months of follow-up. Increased RPE density was identifiable in certain cases, presumably following RPE migration and/or proliferation. New insights into our understanding of anti-angiogenic strategies are gained using PS-OCT.

Back to previous
EURETINA, Temple House, Temple Road, Blackrock, Co Dublin. | Phone: 00353 1 2100092 | Fax: 00353 1 2091112 | Email: euretina@euretina.org

Privacy policyHotel Terms and Conditions Cancellation policy