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Choroidal thickness in patients with diabetic retinopathy

Session Details

Session Title: Vascular Diseases and Diabetic Retinopathy I

Session Date/Time: Thursday 11/09/2014 | 08:00-10:00

Paper Time: 08:24

Venue: Boulevard C

First Author: : R.Leite PORTUGAL

Co Author(s): :    N. Gomes   L. Mendonça   K. Sousa   G. Santos   R. Gentil   F. Vaz

Abstract Details

Purpose:

To evaluate choroidal thickness in patients with diabetic retinopathy using spectral-domain optical coherence tomography.

Setting:

Department of Ophthalmology, Hospital de Braga, Braga, Portugal.

Methods:

One hundred and forty-five eyes of 77 patients with diabetic retinopathy underwent high-definition raster scanning using spectral-domain optical coherence tomography. Exclusion criteria were refractive error higher than ±3 diopters, and a diagnosis of glaucoma. Patients were classified into 3 groups: 40 patients with mild or moderate nonproliferative diabetic retinopathy and no macular edema, 88 patients with nonproliferative diabetic retinopathy and diabetic macular edema, and 17 patients with treated proliferative diabetic retinopathy and no diabetic macular edema. Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction at 500-µm intervals up to 2,500 µm temporally and nasally to the fovea.

Results:

Choroidal thickness showed a pattern of thinning nasally, thickening in the subfoveal region, and thinning again temporally. Mean subfoveal choroidal thickness was lower in patients with diabetic macular edema (198,8±49,5 µm, P < 0.01) or treated proliferative diabetic retinopathy (200,9±50,4 µm, P < 0.05), compared with patients with mild or moderate nonproliferative diabetic retinopathy and no macular edema (236,9 ±54,01 µm).

Conclusions:

Choroidal thickness is altered in diabetes and may be related to the severity of retinopathy. Presence of diabetic macular edema is associated with a decrease in the choroidal thickness. The role of the choroid in the pathophysiology of diabetic retinopathy needs to be further investigated.

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