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Management of macular edema due to diabetes and RVO with intravitreal ranibizumab into a monthly spectral-domain optical coherence tomography based follow-up

Session Details

Session Title: Vascular Diseases & Anterior/posterior segment surgery

Session Date/Time: Sunday 29/09/2013 | 11:00-13:00

Paper Time: 11:56

Venue: Hall 3 (Level 0)

First Author: R.Gallego-Pinazo SPAIN

Co Author(s):    R. Dolz-Marco   S. Martinez-Castillo   M. Pinazo-Duran   P. Hernandez-Martinez     

Abstract Details


To assess the efficacy and safety of intravitreal injections of ranibizumab in patients with naïve macular edema (ME) due to diabetes (DME) and retinal vein occlusions (RVO) in a pro re nata SD-OCT based monthly follow-up therapy approach.


University and Polytechnic Hospital La Fe. Valencia, Spain


The charts of all patients with ME diagnosed between October 2009 and May 2011 were retrospectively reviewed. Inclusion criteria were: diagnosis of diabetes mellitus or retinal vein occlusion (central –CRVO- or branch –BRVO- occlusion), treatment-naïve macular edema and at least 12 months of follow-up. Snellen best-corrected visual acuity (BCVA) and SD-OCT morphometric analysis were collected from baseline and 12-month follow-up visits.


Eighty diabetic patients and 45 patients with BRVO and 20 patients with CRVO met the inclusion criteria. Intravitreal ranibizumab was the only treatment performed through the follow-up, with the first injection administered at the moment of the diagnosis. All patients were followed-up for 12 months. BCVA improved from 0,37+0,25 at baseline to 0,42+0,25 (P=0,044) in DME cases; from 0.28+0.2 to 0.4 +0.25 in BRVO patients and from 0.08+0.07 to 0.29+0.27 (p=0.033) in patients with CRVO. The central subfield thickness decreased from 468.8 + 196.8 at baseline to 368,8 +158,7 microns at 12-months follow-up (P<0,001) in diabetic patients; from 447 +125 to 324+76 microns (p =0.038) in BRVO patients and from 643+148 to 281+57 microns (p=0.001).. The mean number of injections was 3,30+1.5 per patient in 12-month follow-up in diabetic patients; 3.6+1.2 injections per patient in 12-month follow-up in patients with BRVO; and 5.25+1.2 injections per patient in 12-month follow-up in patients with CRVO. There were no local or systemic complications related to the intravitreal injection of ranibizumab.


Our results suggest that intravitreal injections of ranibizumab might be effective and safe in the treatment of DME and ME due to BRVO and CRVO with a pro re nata therapeutic approach. Although we report a monthly SD-OCT follow-up, the mean number of injections was 3.30, 3.6 and 5.25 respectively.

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