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Estimation of oxidative stress level in central serous retinopathy

Session Details

Session Title: Vascular Diseases & Anterior/posterior segment surgery

Session Date/Time: Sunday 29/09/2013 | 11:00-13:00

Paper Time: 11:40

Venue: Hall 3 (Level 0)

First Author: A.Maiti INDIA

Co Author(s):    S. Bose   C. Bhatt   G. Mukherjee   R. Paul     

Abstract Details

Purpose:

This study was to estimate the oxidative stress level in central serous retinopathy

Setting:

Tertiary eye care centre

Methods:

After proper clinical diagnosis supported by Optical coherence tomography(OCT) and digital fundus photography (DFA) the patients’s blood was tested for LPP(Lipid peroxidation product ). To determinate the LPP level, thiobarbituric acid was added to plasma sample under acidic condition, and the absorption of color that developed after heating was estimated spectrophotometrically at 535 nm .1, 1, 3, 3-tetraethoxypropane was used as internal standard and the concentration was expressed in nmol of Malondialdehyde(MDA) per ml of plasma. MDA is a biomarker of the oxidative stress

Results:

Average age of presentation in CSR patients was 40.9 years and 90% were male patients.LPP was estimated in 20 CSR patients and 22 age matched controls. The difference between the two groups was evaluated using a two sample t-test. The test provides evidence of significant higher mean LPP in the CSR patients compared to the control group [p-value < 7.8 X 10 -9] .

Conclusions:

The oxidative stress levels are high in CSR patients . Oxidative stress injury induced lipid peroxidation and the impairment of the antioxidant system may have a potential role in the pathogenesis of the disease especially in the early stage.This study determines the rationale behind the use of antioxidants drugs in the acute stage of CSR .

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