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Vascular endothelial growth factor in Coats' disease

Session Details

Session Title: Vascular Diseases III

Session Date/Time: Sunday 29/09/2013 | 08:00-10:00

Paper Time: 09:44

Venue: Hall 3 (Level 0)

First Author: Q.Zhao CHINA

Co Author(s):    X. Peng   F. Chen   Y. Zhang   L. Wang     

Abstract Details

Purpose:

To examine whether vascular endothelial growth factor (VEGF) as one of the most important intraocular cytokines for angiogenesis and increased vascular permeability is associated with Coats` disease.

Setting:

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China.

Methods:

The clinical interventional study included 28 patients with Coats` disease and 7 control patients with congenital cataract. During intraocular surgery, we obtained aqueous humor samples in which the VEGF concentration was measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Coats` disease was graded into 4 stages.

Results:

The mean aqueous VEGF level was significantly higher in the Coats` study group than in the control group (158±88pg/mL versus 97±21pg/mL; P=0.002). The VEGF concentrations increased significantly (P<0.001) from 91±32pg/mL in Coats` disease stage 2 to 100±37pg/mL in stage 3A1, 185±56pg/mL in stage 3A2 to 256±93pg/mL in patients with stage 3B. VEGF concentrations in Coats` stage 2 and 3A1 did not differ significantly from the values in the control group. Parallel to the association with the stage of the diseases, the VEGF concentrations were significantly (P<0.001) correlated with extent of exudative retinal detachment.

Conclusions:

Increasing severity of Coats` disease is significantly associated with intraocular VEGF concentrations. These results favor the intravitreal application of anti-VEGF drugs as medical therapy of Coats` diseases.

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