Session Title: Vascular Diseases III
Session Date/Time: Sunday 29/09/2013 | 08:00-10:00
Paper Time: 08:56
Venue: Hall 3 (Level 0)
First Author: D.Dossarps FRANCE
Co Author(s): J. Petit B. Guiu J. Cercueil A. Bron
The link between diabetic retinopathy (DR) and adipokines is controversial. Some studies suggest that visceral fat and adipokines could be additional risk factors for diabetic retinopathy. The aim of this study was to determine the relationship between abdominal fat or adipokines secretion and diabetic retinopathy in patients with Type 2 diabetes mellitus (Type 2 DM).
Department of Ophthalmology, University Hospital, Dijon, France
One hundred seventy nine patients with Type 2 DM were included. Each patient underwent measurement of plasma adiponectin and leptin and an evaluation of body fat distribution (visceral and subcutaneous) with MRI. The severity of DR was evaluated with the classification of the American Academy of Ophthalmology (AAO). Patients were classified in 3 groups: absence of DR, mild and moderate DR, advanced DR (severe, proliferative, and diabetic retinopathy treated with laser).
There were no significant differences between the three groups for adiponectin, leptin, visceral or subcutaneous fat accumulation. Patients with DR had a mean duration of diabetes, serum creatinine concentration and percentage of macroalbuminuria significantly higher than patients without DR (P < 0.001, P = 0.003 and P < 0.001, respectively). Serum adiponectin increased with the diabetic nephropathy stage (P = 0.007).
Our study suggests that body fat distribution and adipokines secretion are not associated with diabetic retinopathy in patients with Type 2 DM.