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Intravitreal bevazicumab for retinopathy of prematurity: refractive error results

Session Details

Session Title: Vascular Diseases III

Session Date/Time: Sunday 29/09/2013 | 08:00-10:00

Paper Time: 08:32

Venue: Hall 3 (Level 0)

First Author: J.Jonas GERMANY

Co Author(s):    B. Harder   F. Schlihctenbrede   S. von Baltz   W. Jendritza     

Abstract Details


To evaluate refractive error in infants who underwent intravitreal bevacizumab injection for treatment of threshold retinopathy of prematurity (ROP).


Hospital-based study


The study group included all infants who consecutively received a single intravitreal bevacizumab (0.375 mg or 0.625 mg) injection for therapy of threshold ROP in fundus zone I or zone II. The control group included infants who had previously undergone retinal argon laser therapy of ROP. The follow-up examination included refractometry under cylcoplegic conditions.


The study group included 12 children (23 eyes; mean birth weight:622±153g; gestational age:25.2±1.6 weeks) and the control group included 13 children (26 eyes; birth weight:717±197g; gestational age:25.3±1.8 weeks). Both groups did not differ significantly in birth age and weight and follow-up. At the end of follow-up at 11.4±2.3 months after birth, refractive error was less myopic in the study group than in the control group (-1.04±4.24 diopters (median:0 diopters) versus -4.41±5.50 diopters (median:-5.50 diopters);P=0.02). Prevalence of moderate myopia (17±8% versus 54±10%; P=0.02; OR:0.18 (95%CI:0.05,0.68) and high myopia (9±6% versus 42±10%;P=0.01; OR:0.13 (95%CI:0.03,0.67) was significantly lower in the bevacizumab group. Refractive astigmatism was significantly lower in the study group (-1.0±1.04 diopters versus 1.82±1.41 diopters; P=0.03). In multivariate analysis, myopic refractive error and astigmatism were significantly associated with laser therapy versus bevacizumab therapy (P=0.04 and P=0.02, respectively).


In a one-year follow-up, a single intravitreal bevacizumab injection as compared to conventional retinal laser coagulation was helpful for therapy of ROP and led to less myopization and less astigmatism.

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