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Outer retinal tubulation in neovascular age-related macular degeneration treated with ranibizumab

Session Details

Session Title: AMD III

Session Date/Time: Sunday 29/09/2013 | 11:00-13:00

Paper Time: 11:24

Venue: Hall G1 (Level 2)

First Author: C.Gianniou SWITZERLAND

Co Author(s):    L. Marchionno   D. Decugis   I. Mantel        

Abstract Details

Purpose:

Outer Retinal Tubulation (ORT) may mimic intraretinal cysts in neovascular AMD (nAMD). The purpose of this study was to investigate the incidence of ORT in nAMD treated with anti-VEGF treatment (ranibizumab) and to describe the time course of the appearance of ORT.

Setting:

Retrospective study.

Methods:

Retrospective study of eyes with nAMD, treated with intravitreal ranibizumab as needed, and followed from baseline with spectral domain optical coherence tomography (SD-OCT, cube examination). Data was collected for age, eye, angiographic type of nAMD, presence of atrophy, longitudinal visual acuity (VA), and ORT findings on OCT.

Results:

The study included 620 eyes of 557 patients with a mean age of 78 years. ORT was found with any angiographic type of nAMD, its occurrence will be described as a Kaplan Meier survival curve: 15% of patients showed signs of ORT on SD-OCT, appearing after a mean of 17 months (range 0- 48 months) from baseline. Two thirds of ORT lesions were associated with underlying atrophy. Typical ORT lesions (round tubuli) often were preceded by dome-shaped precursors during a few months.

Conclusions:

ORT is a common finding in nAMD under treatment with anti-VEGF, with increasing prevalence over time. Its recognition is essential to avoid over-treatment due to misinterpretation as exudative sign.

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