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Outer retinal tubulation in neovascular age-related macular degeneration treated with ranibizumab

Session Details

Session Title: AMD III

Session Date/Time: Sunday 29/09/2013 | 11:00-13:00

Paper Time: 11:24

Venue: Hall G1 (Level 2)

First Author: C.Gianniou SWITZERLAND

Co Author(s):    L. Marchionno   D. Decugis   I. Mantel        

Abstract Details


Outer Retinal Tubulation (ORT) may mimic intraretinal cysts in neovascular AMD (nAMD). The purpose of this study was to investigate the incidence of ORT in nAMD treated with anti-VEGF treatment (ranibizumab) and to describe the time course of the appearance of ORT.


Retrospective study.


Retrospective study of eyes with nAMD, treated with intravitreal ranibizumab as needed, and followed from baseline with spectral domain optical coherence tomography (SD-OCT, cube examination). Data was collected for age, eye, angiographic type of nAMD, presence of atrophy, longitudinal visual acuity (VA), and ORT findings on OCT.


The study included 620 eyes of 557 patients with a mean age of 78 years. ORT was found with any angiographic type of nAMD, its occurrence will be described as a Kaplan Meier survival curve: 15% of patients showed signs of ORT on SD-OCT, appearing after a mean of 17 months (range 0- 48 months) from baseline. Two thirds of ORT lesions were associated with underlying atrophy. Typical ORT lesions (round tubuli) often were preceded by dome-shaped precursors during a few months.


ORT is a common finding in nAMD under treatment with anti-VEGF, with increasing prevalence over time. Its recognition is essential to avoid over-treatment due to misinterpretation as exudative sign.

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