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High resolution doppler OCT microangiography and blood flow assessment in patients with retinal and/or choroidal vascular pathologies

Session Details

Session Title: Imaging II

Session Date/Time: Sunday 29/09/2013 | 08:00-10:00

Paper Time: 08:56

Venue: Hall G1 (Level 2)

First Author: C.Mitsch AUSTRIA

Co Author(s):    C. Blatter   U. Schmidt-Erfurth   R. Leitgeb        

Abstract Details

Purpose:

To assess the blood flow dynamics quantitatively independent of the axial Doppler angle and to contrast the microvasculature network of the posterior segment in patients with distinct retinal vascular pathologies such as diabetic retinopathy, retinal vein occlusion, central serous chorioretinopathy and choroidal neovascularization using a bidirectional dual beam Doppler high-speed Swept Source OCT System at 1060nm

Setting:

Department of Ophthalmology and Center of Medical Physics and Biomedical Engineering of the Medical University of Vienna

Methods:

Traditional Doppler OCT is highly sensitive to motion artifacts due to the dependence on the Doppler angle, limiting its accuracy in clinical practice. To overcome this limitation, we use a bidirectional dual beam platform with flexible aligning of the incidence plane allowing reconstruction of the true flow velocity in the range of 5 to 500mm/s. Microangiography is used to assess the vascular network branching and integrity. Patients were examined during a single-visit examination performing traditional fluorescein angiography, SD-OCT retinal imaging and Doppler-OCT imaging

Results:

Highly sensitive flow contrasting has been performed at selected pathological location in patients with diabetic retinopathy, retinal vein occlusion, central serous chorioretinopathy and choroidal neovascularisiation. It reveals specific alterations of the vascular network, like signs of vessel density loss, showing correlation with fluorescence angiography

Conclusions:

We apply a dual beam bidirectional Doppler OCT system to accurately quantify flow dynamics and for non-invasive 3D microangiography of the posterior segment in the human eye. We present measurements performed in patients with distinct retinal vascular pathologies such as diabetic retinopathy, retinal vein occlusion, central serous chorioretinopathy and choroidal neovascularization. The motion artifact stable and accurate flow quantification and visualization may therefore lead ultimately to a better understanding and an enhanced early diagnosis of retinal vascular diseases

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