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Structural and functional changes in chronic central serous chorioretinopathy treated with photodynamic therapy

Session Details

Session Title: Quick Fire Free Paper Session 04

Session Date/Time: Sunday 29/09/2013 | 11:00-13:00

Paper Time: 12:30

Venue: Hall C (Level 1)

First Author: S.Leal PORTUGAL

Co Author(s):    H. Vasconcelos   A. Santos   J. Figueira   I. Pires     

Abstract Details

"Purpose:

To evaluate structural and functional retinal changes in chronic central serous chorioretinopathy (cCSC) treated with photodynamic therapy (PDT) after 5 years of follow-up.

Setting:

AIBILI – Association for Innovation and Biomedical Research on Light and Image; Ophthalmology Unit, Centro Hospitalar e Universitário de Coimbra

Methods:

A retrospective study including patients with cCSC treated with standard PDT and followed for 5 or more years. At the final visit all patients underwent full ophthalmic evaluation, functional analysis with microperimetry and structural analysis with Spectralis optical coherence tomography (OCT). Measurements made at the fovea included central retinal thickness (CRT), neuroretinal thickness (NRT), external nuclear layer (ENL) thickness and subfoveal choroidal (SFC) thickness.

Results:

Seventeen eyes of 15 patients were included. Final visual acuity (VA) was correlated to baseline VA (p<0.001; r=0.93) and baseline NRT thickness (p<0.01; r=0.69) but not baseline CRT or age. Final VA was also correlated with final CMT (p<0.001; r=0.79), final NRT (p<0.001; r=0.70) and inner and outer segment layers thickness (p=0.001; r=0.71), but not with ENL thickness or SFC thickness. Microperimetry sensitivity was correlated with final VA (p<0.001; r=0.896).

Conclusions:

Baseline NRT and VA are associated with the final functional outcome. Baseline CRT is not correlated due to variable subretinal fluid. At the final visit, foveal changes at the inner and outer segment layers, but not the ENL or choroid, correlate with the functional outcome in cCSC patients treated with PDT."

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