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The use of intravitreal bevacizumab (Avastin) before pars plana vitrectomy in patients with proliferative diabetic retinopathy

Session Details

Session Title: Quick Fire Free Paper Session 04

Session Date/Time: Sunday 29/09/2013 | 11:00-13:00

Paper Time: 11:50

Venue: Hall C (Level 1)

First Author: T.Imshenetskaya BELARUS

Co Author(s):    I. Igumnova   V. Yarmak   I. Malinovskaya        

Abstract Details

"Purpose:

To evaluate the effectiveness and safety of the using the single injection bevacizumab (Avastin), injected before surgery in patients with proliferative diabetic retinopathy.

Setting:

Belarusian Medical Academy of Post-Graduate Education, 10th Minsk City Clinical Hospital, Minsk, Belarus

Methods:

We studied 18 eyes (13 patients): 7 men (54%) and 6 women (46%) with proliferative diabetic retinopathy, average age 46,3. 7 eyes (38,9%), undergoing surgery for nonclearing vitreous hemorrhage and PDR and 16 eyes (88,9%) - severe PDR and tractional retinal detachment. Intravitreal bevacizumab 1.25 mg/0.05 ml was injected 3 to 5 days before vitrectomy. Standard three port vitrectomy was performed using 20 – or 23 – gauge.

Results:

13 eyes (72,3%) underwent PPV and gas infusion (SF6). All cases showed minimum bleeding during pars plana vitrectomy. Recurrent vitreous hemorrhage in the early postoperative period was noted only in one eye (5,6%), increasing of the vitreoretinal traction occurred in 3 eyes (16,7%), traction retinal detachment – in one eye (5,6%). Post-operative BCVA improved in 16,7%.

Conclusions:

Preoperative use of bevacizumab in the treatment of severe diabetic retinopathy was well tolerated, reduced active neovascularization, that facilitated pars plana vitrectomy, significantly reduced the occurrence of postoperative vitreous hemorrhage."

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