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Intra-silicone oil injection of bevacizumab at the end of retinal reattachment surgery for severe proliferative vitreoretinopathy

Session Details

Session Title: Quick Fire Free Paper Session 03

Session Date/Time: Sunday 29/09/2013 | 08:30-09:30

Paper Time: 08:05

Venue: Hall C (Level 1)

First Author: K.Ghasemi Falavarjani IRAN

Co Author(s):    M. Hashemi   M. Modarres           

Abstract Details


To evaluate the role of bevacizumab injected into the silicone oil at the end of retinal reattachment surgery for rhegmatogenous retinal detachment (RRD) associated with severe proliferative vitreoretinopathy (PVR) for prevention of postoperative PVR and compare the results with those without intrasilicone injection.


Tehran University of Medical Sciences


In this prospective comparative interventional study, eyes with RRD with grade C PVR were included. Standard 20 gauge parsplana vitrectomy, and retinal reattachment was performed. In case group, 1.25 mg bevacizumab was injected into the silicone oil at the end of surgery. The rate of retinal redetachment associated with PVR was assessed.


Thirty-eight eyes of 38 patients (18 cases and 18 controls) with a mean age of 46.6±18.3 years were studied. The two groups were matched for age, sex, preoperative visual acuity, extent of PVR and history of previous retinal detachment surgery. Retinal redetachment with PVR occurred in 9 (47.3%) and 7 (36.8%) eyes in case and control groups, respectively (P=0.5). Extensive subretinal fibrous proliferations in addition to preretinal membranes occurred more in the case group (55.5% vs 11.1%). At final visit, visual acuity was similar between the two groups (1.6±0.8 and 1.6±0.6, respectively, P=0.9).


Intra-silicone injection of bevacizumab at the end of vitrectomy for RRD with severe PVR does not eliminate the risk of postoperative PVR.

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