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Determination of the growth/differentiation factor-15 levels of the vitreous

Session Details

Session Title: Vitreoretinal Surgery III

Session Date/Time: Friday 27/09/2013 | 11:00-12:30

Paper Time: 11:00

Venue: Hall 3 (Level 0)

First Author: A.Bilgin TURKEY

Co Author(s):    H. ?lhan   A. Toylu   K. Apayd?n        

Abstract Details

Purpose:

To determine the Growth/differentiation factor-15 (GDF-15) protein levels in the vitreous samples of patients with different vitreoretinal pathologies.

Setting:

Akdeniz University Ophthalmology Department, Antalya, Turkey

Methods:

Vitreous samples from 40 patients with different vitreoretinal pathologies like; vitreous hemorrhage (VH), vitreomacular traction (VMT), epiretinal membrane (ERM), macular hole (MH), rhegmatogenous retinal detachment (RRD) and retained lens particles were collected prior to pars plana vitrectomy. GDF-15 levels were measured with ELISA method in the vitreous samples.

Results:

GDF-15 levels of the vitreous samples from MH and RRD patients were significantly lower than that of other pathologies. Diabetic patients with retinal pathologies were found to have a 2-fold increased levels of GDF-15 compared to non-diabetic patients.

Conclusions:

This is the first study to present GDF-15 growth factor levels of vitreous samples, to the best of our knowledge. The high levels of GDF-15 in diabetic patients and the significantly low levels in MH and RRD patients may be due to the presence of blood and inflammation in diabetics and relatively low inflammation in MH and RRD. To understand the role of GDF-15 in vitreoretinal pathologies, further studies focusing on the expression of GDF-15 in vitreous and retinal cells should be performed.

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