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Age macular degeneration-alzheimer disease- relevance and interest of OCT, OCT en face exam in detection and in follow-up of AMD and Alzheimer disease

Session Details

Session Title: AMD II

Session Date/Time: Friday 27/09/2013 | 08:00-10:00

Paper Time: 08:40

Venue: Hall 3 (Level 0)

First Author: C.Gonzalez FRANCE

Co Author(s):                  

Abstract Details

Purpose:

To evaluate the importance of OCT en Face exam in AMD and AD, the impact of AMD on Alzheimer disease and vice versa, and their in-between correlation and relationship.

Setting:

Interventional, non comparative, retrospective case series

Methods:

PATIENTS: AMD patients: 154 patients, 3 Groups A, B, C. A: 35 AMD patients with first stage AMD (drusen, drusenoid PED, pigment, small atrophic areas), B: 48 Atrophy AMD patients with predominant atrophic areas, C: 71 Neovascular AMD patients. EXAM: is focused on Optical Coherence Tomography exam (Spectral Domain OCT (Spectralis HRA+OCT)), particularly OCT en face software, add ophthalmologic exam including ETDRS visual acuity (VA), complete ophthalmic examination, Fundus examination, autofluorescence imaging (FAF), (Region Finder Software, particularly for atrophic areas), and fluorescein angiography (FA) and ICG when Neovascular complication. Cognitive evaluation is done with MMSE: Mini Mental State Examination (Folstein, GRECO), score allow to determine 4 groups.I: Normal or no significative patients; II: MCI patients,( 4 subgroups: mild, moderate, intense , severe); III : Early AD; IV:AD.

Results:

OCT en Face allow to study the structure of each retinal layer , particularly RPE, Photoreceptor one ,characteristics, surface , volume, topography of AMD lesions( drusen, PED, atophy, neovascular net). Cognitive impairment depends on AMD subgroups: mild groupA ( normal score :37%) , more intense group B(normal score:22,5%)/ group C( normal score: 34%), early Alzheimer disease only in group C(3%). MCI: 73% group A, 77,5% group B,63% group C. AMD is present in 43% patients with cognitive impairment. The AMD evaluation, characteristics, classification, particularly with en Face OCT allow Alzheimer disease screening and follow-up. Ophthalmologic exam let screening, characterization, evaluation of both AMD and AD pathologies, sub-group individualization with different prognosis, AMD type and state dependent. Similarities, correlations between AMD and AD are enhanced and etiopathogenics ways too.

Conclusions:

Ophthalmologic exam, en Face OCT allow to improve diagnosis, follow-up, screening of AMD and AD and their in between relationship and correlations, furthermore progress in etiopathogenic knowledge and therapeutic prospects.

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