Session Title: Vascular Diseases II
Session Date/Time: Friday 27/09/2013 | 11:00-12:30
Paper Time: 11:08
Venue: Hall F (Level 2)
First Author: I.Govindaraj INDIA
Co Author(s): N. Sampath K. Gupta N. Yadav R. Battu
To study venous changes over the first major arteriovenous (AV) crossing by SDOCT in normal individuals, hypertensive patients and in those with BRVO
The study was conducted at Narayana Nethralaya, Banglore, India from January 2013 to February 2013.
The study consisted of three groups. Group one consisted of 20 normal individuals, group two had 20 hypertensive patients and group three had 20 BRVO patients. SD OCT (Heidelberg Spectralis) was done in both the eyes of all individuals. Longitudinal section through the first major AV crossing was done in the superotemporal and inferotemporal quadrants of both eyes. The vessel diameter was studied before and at the crossing by manually measuring the blood column of the vein. The extent of kinking of the underlying blood vessel was studied by noting whether the vessel wall touched the IS/OS junction or the RPE. Statistics was done using SPSS version 17.The narrowing of the vein at the AV crossing was compared between the 3 groups using one way ANOVA Test. The correlation between the extent of vein kinking and the narrowing at the AV crossing was done by Spearman correlation. a p value of < 0.05 was taken as significant.
Mean age was 31.5±4.5, 51.8±9.2 and 54.4±1.3 years in group 1,2 and 3 respectively. Average duration of hypertension in group 2 and group 3 was 5.5±3.3 and 6.8±4.2 years respectively. In group 3, eight patients had superotemporal BRVO and 12 had inferotemporal BRVO. The difference in the vessel caliber was compared between group 1 and 2, group 2 and 3, and group 1 and 3 respectively. Between group 2 & 3 there was no significant difference ( p=1) whereas between groups 1 & 2 and 1 & 3 there was a significant difference in the vessel caliber (p<0.01). In addition to artery crossing over vein 4 eyes in group 1, 8 eyes in group 2 and 5 eyes in group 3 had vein crossing over the artery. No significant correlation was found between the extent of kinking and the extent of compression of the vein in group 1 and group 3 whereas there was a significant positive correlation in group 2.
This study shows an in vivo evidence of venous narrowing at the arteriovenous crossing in hypertensive patients and those with BRVO. The narrowing can also be a part of atherosclerotic changes and hence an indirect measure of the atherosclerosis. Age matched controls may show that hypertensives have more narrowing of veins in AV crossing. More studies correlating the venous compression at AV crossing with atherosclerotic markers like serum cholesterol, CRP etc may give us further insight on risk of thromboembolic events.