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Vitreous transferrin and prealbumin in proliferative vitreoretinopathy and recurrence of retinal detachment

Session Details

Session Title: Vitreoretinal Surgery II

Session Date/Time: Thursday 26/09/2013 | 14:30-16:00

Paper Time: 15:02

Venue: Hall 3 (Level 0)

First Author: C.Arndt FRANCE

Co Author(s):    L. Ramon   C. Boulagnon   G. Bonnay        

Abstract Details

Purpose:

Proliferative vitreoretinopathy is the leading cause of failure in retinal detachment surgery. Among different factors two vitreous proteins, transferrin and prealbumin have been associated with PVR. The purpose was to look for a link between the vitreous concentration of these two proteins and the post-operative outcome.

Setting:

Prospective follow up study

Methods:

The vitreous samples of patients with either rhegmatogenous retinal detachment or macular surgery (control group) were obtained at the initial phase of surgery without previous intraocular infusion. The concentration of transferrin and prealbumin were determined in all cases. The functional (visual acuity) and anatomical outcome (reattachment, OCT mean foveal thickness) was assessed.

Results:

Retinal detachment surgery has been performed in 40 patients and macular surgery in 49 patients. There was a significant difference between the mean vitreous concentration in patients treated for retinal detachment (transferrin : 156 mg/l, prealbumin : 88 mg/l) and patients undergoing macular surgery (transferrin 68 mg/l, prealbumin : 22 mg/l). In the group of patients with retinal detachment and surgical failure due to PVR, the vitreous concentration of prealbumin and transferrin was significantly higher than in patients with successful reattachment (respectively p=0,013 et p=0.011).

Conclusions:

Increased vitreous prealbumin and transferrin appear to correlate with a higher risk of failure in retinal detachment surgery. The predictive value of these proteins for the occurrence of postoperative proliferative vitreoretinopathy in patients undergoing retinal detachment surgery remains to be demonstrated in further studies.

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