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Fundus autofluorescence patterns in central serous chorioretinopathy

Session Details

Session Title: Imaging I

Session Date/Time: Thursday 26/09/2013 | 08:30-10:30

Paper Time: 09:18

Venue: Hall 3 (Level 0)

First Author: S.Yu SOUTH KOREA

Co Author(s):    H. Kwak              

Abstract Details

Purpose:

To investigate the patterns and frequency of fundus autofluorescence (FAF) abnormalities in patients with central serous chorioretinopathy (CSC) and evaluate correlation with spectral-domain optical coherence tomography (SD-OCT) findings and best-corrected visual acuity (BCVA).

Setting:

The study was carried out in Kyung Hee University Hospital, Seoul, Korea.

Methods:

Cross-sectional observational study, in which 127 eyes of 119 consecutive patients with CSC underwent fundus photography, FAF imaging, fluorescein angiography (FA), indocyanine green angiography (ICGA) and SD-OCT.

Results:

The mean age of subjects was 46.5±9.2 years, and 101(84.9%) were male. Alterations in FAF were classified into five patterns: blocked(43.3%), mottled(8.7%), hyper(27.6%), hyper/hypo(11.0%) and descending tract(9.4%). There are blocked(63.1±156.2 days), mottled(197.9±222.4 days), hyper(379.2±559.7 days), hyper/hypo(987.5±1050.0 days), and descending tract AF group(1363.8±1352.4 days), in order by the length of duration of symptom (p<0.001). The mean visual acuity (logMAR) was 0.24±0.29 for the blocked, 0.36±0.31 for the mottled, 0.36±0.33 for the hyper, 0.51±0.38 for the hyper/hypo, and 0.38±0.32 for the descending tract AF group. The mean visual acuity in the blocked AF group was better to a statistically significant extent (p=0.045, respectively). Ninety-five of 119 patients undergone OCT. Intact inner/outer segment junction on SD-OCT are 39 eyes (100%) in the blocked, 9 eyes (90%) in mottled, 23 eyes (82.1%) in hyper, 3 eyes (37.5%) in hyper/hypo and 3 eyes (30.0%) in descending tract AF group (p=0.000). Disrupted external limiting membrane line on SD-OCT was found in only 1 patient in descending tract group while not being found in other groups.

Conclusions:

The FAF abnormalities in CSC show multiple distinct patterns and seem to correlate with duration of symptom and BCVA. A refined phenotypic classification may be helpful to discern chronicity.

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