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Multicenter anti-VEGF trial in Austria- the Manta study

Session Details

Session Title: AMD I

Session Date/Time: Thursday 26/09/2013 | 08:30-10:30

Paper Time: 08:38

Venue: Hall 1 (Level 2)

First Author: S.Binder AUSTRIA

Co Author(s):    I. Krebs   L. Schmetterer           

Abstract Details

Purpose:

Report of an observer and subject masked trial comparing the visual outcome after treatment with Ranibizumab or Bevacizumab in patients with neovascular age-related macular degeneration

Setting:

Non inferiority study based on the data of MARINA, ANCHOR and FOCUS studies. 320 patients with NV AMD included in this prospective double blinded multicenter trial

Methods:

Patients with neovascular AMD were randomized to treatment of either 0.5 Ranibizumab or 1,25mg Bevacizumab. After three initial monthly injections eyes patients were treated in a as needed regimen. Monthly assessed best corrected best corrected distance acuity (BCDVA), retinal thickness and adverse events assessment were the main points of interest.

Results:

321 patients were randomized, 4 excluded so that a total of 317 eyes were evaluated. BCDVA after one year was equivalent between bevacizumab ( 4.9 letters after 12 months) and ranibizumab (4.1 letters after 12 months). Mean number of treatments was also similar: 5.8x in the ranibizumab group and 6.1x in the bevacizumab group. Retinal thickness measurements showed a decrease of 89.9µm for ranibizumab and 86.3µm for bevacizumab, p=0.81). Serious adverse events were observed in 9.2 % in the ranibizumab group and in 11.6 % in the bevacizumab group.

Conclusions:

Bevacizumab was equivalent to ranibizumab at all time points for one year. Neither the total number nor the number of adverse events in any subgroup was significant different.

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