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Evaluation of retinal and choroidal thickness changes after single anti-VEGF injection in neovascular age-related macular degeneration: comparison of ranibizumab with bevacizumab

Session Details

Session Title: Quick Fire Free Paper Session 01

Session Date/Time: Thursday 26/09/2013 | 08:30-10:30

Paper Time: 08:30

Venue: Hall G1 (Level 2)

First Author: M.Zengin TURKEY

Co Author(s):    C. Kucukerdonmez   S. Sizmaz   A. Kal   G. Yilmaz     

Abstract Details

Purpose:

To evaluate and compare the effects of single intravitreal injection of ranibizumab and bevacizumab on central retinal and choroidal thickness in patients with neovascular age-related macular degeneration (AMD)

Setting:

Prospective, randomized, interventional study

Methods:

Forty eyes of 40 patients with neovascular AMD that underwent intravitreal injection of vascular endothelial growth factor inhibitors (anti-VEGFs) were included. Patients were randomized into two groups: Twenty eyes received ranibizumab and 20 eyes received bevacizumab injection. Central retinal and choroidal thicknesses of all eyes at baseline and 1 month post-injection scans were measured with Fourier-domain optical coherence tomography (OCT). Choroidal thickness measurements were taken at 7 points, with the fovea at the center. Student t test and Mann Whitney U test were used to compare the data.

Results:

The mean central retinal thickness (CRT) showed significant decrease after single injection of ranibizumab (from 345.0 microns to 253.5 microns, p<0.01) and bevacizumab (from 329.5 microns to 251.0 microns, p<0.01) at the first month, respectively. There was no significant difference regarding the CRT change between groups (p=0.39). The mean choroidal thickness decreased from 158.6 microns (115 – 317) to 155.5 microns (111 – 322) in ranibizumab group and from 211.5 microns (143 – 284) to 201.5 microns (93 – 338) in bevacizumab group. The decrease was not significant between groups (p=0.35).

Conclusions:

Intravitreal injection of both ranibizumab and bevacizumab provided a significant decrease in central retinal thickness, however, both agents caused no significant change in choroidal thickness. Further studies are required to confirm the effect of anti-VEGF agents on choroid, which is assumed to play a role in the pathogenesis of AMD.

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