Surgical treatment of submacular haemorrhage with tissue plasminogen activator

Poster Details

First Author: T.Stavropoulou GREECE

Co Author(s):    D. Pagoulatos   P. Dimitrakas   P. Petrou   I. Georgalas                    

Abstract Details


To assess the efficacy of intravitreal injection of OCT-Afluoropropane (C3F8) gas in combination with tissue plasminogen activator (tPA) for displacing submacular haemorrhage.


Α University clinic of ophthalmology, GNA Gennimatas


20 cases of submacular haemorrhage were treated with 23G pars plana vitrectomy,subretinal injection of tPA and C3F8 gas intravitrealy. Submacular haemorrhage was related to exudative age-related macular degeneration (AMD) in 12 eyes and ruptured retinal arterial macroaneurysms in 8 eyes.


Compared with the preoperative VA (follow-up of 12 months), the final visual acuity (VA) improved by 3/10 in 12 eyes (60%), stabilized in 4 eyes (20%), and deteriorated in 4 eyes (20%). In eyes with AMD, haemorrhage including vitreous haemorrhage recurred in 3 (25%) of 12 eyes treated . In eyes with macroaneurysms, haemorrhage recurred in 2 cases (25%).2 eyes underwent vitrectomy for recurrent haemorrhage. During follow-up, intravitreal ranibizumab was administered in 5 (41.6%) of 12 eyes with AMD. No other complications were observed.


Intravitreal C3F8 gas plus tPA provide good visual outcomes and no remarkable complications for treating submacular haemorrhage.

Back to previous
EURETINA, Temple House, Temple Road, Blackrock, Co Dublin. | Phone: 00353 1 2100092 | Fax: 00353 1 2091112 | Email:

Privacy policyHotel Terms and Conditions Cancellation policy