First Author: R.Zainullin RUSSIA
Co Author(s): M. Bikbov R. Fayzrakhmanov V. Salavatova M. Kalanov
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To analyze the changes in retinal sensitivity in patients with diabetic macular edema caused by the anti-VEGF therapy.
Ufa Eye Research Institute, Ufa, Russia
We examined 38 patients (39 eyes) with diabetic macular edema caused by diabetes Type 2. Microperimetry (MP1; Nidek Technologies, Padova, Italy). All patients underwent an anti-VEGF therapy with ranibizumab in the surgical room under local anaesthesia in a dose of 0.5 mg.
Based on the microperimetry of the central zone of the retina, in patients with diabetic macular edema fixation gaze remained a central and stable, and the fixation region size did not exceed 4°. Indicators of the retinal sensitivity were reduced by an average of 9 dB in comparison with the norm and amounted to 9.85 ± 0.12 dB. After stimulus contacted the region with hard exudates, we observed greater decrease in the sensitivity (up to 0 dB) in comparison with the area of macular edema (up to 4 dB). Correlation analysis of the structural (thickness of the retina) and functional (retinal sensitivity) parameters resulted in a moderate inverse correlation (r = -0.57; p=0.035) The average value of retinal sensitivity after treatment was 12.45 ± 0.19 dB (p = 0.021). In 79.4% of patients, as a result of the treatment, the best-corrected visual acuity increased from 0.93 ± 0.04 to 0.79 ± 0.07 LogMAR (p = 0.032), on average.
After the anti-VEGF therapy in patients with diabetic macular edema we observed an increase in retinal sensitivity as well as the improvement in visual acuity. We discovered a moderate inverse correlation between the thickness and sensitivity of the retina.