First Author: N.Tanji JAPAN
Co Author(s): S. Kato T. Shiraya F. Araki
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Fluorescein angiography (FA) is primarily used to distinguish between neovascular vessels (NV) and intraretinal microvascular abnormalities (IRMA). However, FA has a risk of systemic side effects. Here, we investigated the characteristics of NV and IRMA using optical computed tomography angiography (OCT-A) and assessed whether OCT-A can be used to distinguish the two conditions.
Department of Ophthalmology, the University of Tokyo Hospital, Tokyo, Japan
Eleven eyes of 10 patients diagnosed with diabetic retinopathy (DR), from January 1 to May 5, 2016, who underwent both FA and OCT-A (RTVue XR Avanti, Optovue), were included in this retrospective study. First, we defined NV as abnormal retinal blood vessels observable in FA, and IRMA as vessels without leakage. We examined whether abnormal vessels beyond the inner limiting membrane (ILM) were visible using OCT-A. Second, NV activity was classified into three levels (mild, moderate, or severe) according to the degree of leakage observed in FA, and morphological features were assessed using OCT-A. Then, the presence or absence of IRMA near NV was examined using OCT-A.
Using FA, 17 NV of nine eyes were detected. Abnormal vessels beyond the ILM were detected by OCT-A in all NV identified by FA. All NV with mild activity (9 areas) were tubular, and all NV with severe activity (5 areas) were dendritic. Of 17 NV, 14 (82.4%) were near IRMA and remaining NV were not near IRMA.
Results of the diagnosis and activity evaluation of NV using OCT-A were similar to those obtained using FA, suggesting that OCT-A may be useful for diagnosis of NV in patients with DR.