A systematic review of the frequency and type of patient-reported outcome measures in randomised controlled trails on diabetic macular oedema.

Poster Details

First Author: T.Patterson UK

Co Author(s):    J. McBurney   A. Azuara Blanco                          

Abstract Details


Diabetic eye disease in developed countries is the leading cause of vision loss in adults between the ages of 20 and 75. Therefore a significant functional gain to be achieved by the treatment of this condition. It is these functional gains which patient reported outcome measures (PROMs) record, allowing decisions regarding the efficacy of treatment in real world terms. The aim of this study is to systematically review the DMO RCTs conducted within the last 5 years (1st January 2011 - 1st December 2016), to assess the usage and type of PROMs being reported.


This study was conduct as a systematic review of the literature by students based at Queen's University Belfast.


To accomplish this a systematic review was conducted. Five journal databases were searched - PubMed, Web of Science, Ovid Embase/Medline, SCOPUS and Cochrane Library - additionally 4 trial registries - ISRCTN Register,, International Clinical Trials Registry Platform and the EU Clinical Trials Registry - were searched from 1st January 2011 to 1st December 2016. Two masked investigators were involved in data extraction.


This search resulted in 11 975 titles. After screening and the exclusion of duplicates this was reduced to a final 261 trials. Of these 261 trials 35 (13.4%) contained PROMs, the most common being the NEI-VFQ-25 with its inclusion in 25 trials. In total 8 other PROMs were identified, with the second most common being the EQ-5D (14 trials).


Patient reported outcome measures are not commonly reported in patients with DMO.

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