First Author: C.Monia TUNISIA
Co Author(s): O. Meriem S. Hela K. Amine M. Insaf B. Jihen
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To quantify the foveal avascular zone (FAZ) area in eye with macular edema asociated to branch retinal vein occlusion (BRVO) and compared with the follow eye using OCT-Angiography.
Ophthalmology department Habib Thameur hospital, 8 street Ali Ben Ayed Montfleury 1008 Tunis, TUNISIA.
In this prospective observational case series, 9 patients with unilateral BRVO involving the macula were enrolled. All patients underwent ophthalmic examination including best-corrected visual acuity (BCVA), fluorescein angiography (FA), Swept-source OCT (SS-OCT) and OCT-Angiography (OCT-A) of BRVO eyes and their follow eyes as control group. FAZ area was quantified and microvascular abnormalities were analyzed in both superficial capillary plexus and deep capillary plexus on OCT-A using 4,5 x 4,5 mm angiograms.
The mean age of patients was 55.86 (± 9.06) years. Eight eyes had cystoid macular edema and 7 eyes had ellipsoid zone (ZE) disruption on SS-OCT. Capillary non-perfusion on OCT-A was seen in 7 eyes and significantly correlated with poor visual acuity (p=0.01). Retinal capillary network abnormalities were seen in deep capillary plexus of 4 eyes and in superficial capillary plexus of 5 eyes. Collaterals appeared in only one eye. Vascular tortuosity appeared in deep capillary plexus of 7 eyes and in superficial capillary plexus of 6 eyes. There was not any microvascular abnormality in fellow eyes. Mean FAZ area was 608,047 µm in BRVO eyes compared to 359.96 µm in healthy eyes. There was a significant correlation between FAZ area and poor visual acuity (p<0.001).
OCT-A is a non-invasive imaging technique that can help quantify FAZ enlargement and analyze microvascular abnormalities in BRVO eyes. It may be a good tool for diagnosis and follow-up and for establishing a functional prognosis in patients with macular edema.