First Author: A.Machalińska POLAND
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Hypertension (HT) strongly affects vascular endothelium resulting in chronic inflammatory disease. Dynamic vessel analysis (DVA) represents a modern methodological approach to analyze vascular function in the retinal microcirculation. The aim of our study was to examine if defective retinal vessels response is causally linked to HT-induced endothelium dysfunction.
Pomeranian Medical University
Retinal vessel reaction to flicker stimulation was examined by DVA in both eyes of 37 hypertensive and 41 healthy control subjects. Plasma concentrations of C-reactive protein (CRP), interleukin-6 and tumour necrosis factor alpha (TNFɑ) were measured by enzyme-linked immunosorbent assay.
Both arterial and vein response to flicker stimulation was significantly decreased in the patients with HT compared to the healthy controls (DVA of arteries lower in HT group by 1.31 on average, p=0.0001 and DVA of veins lower in HT group by 1.32 on average, p=0.0001) after independent adjustment for age, sex, body mass index and pressure values. In the hypertensive group, negative correlation between arterial response to flicker stimulation and plasma CRP concentration (Rs=-0.27, p=0.02) was observed. Similarly, plasma TNFα concentrations negatively correlated with arterial response to flicker stimulation (Rs=-0.39, p=0.0008).
Our results indicate that DVA directly reflects the actual metabolic status of retinal endothelium. It might be used as an early non-invasive screening tool to detect vascular dysregulation and pan-endothelial dysfunction in patients with hypertension.