Posters

The effects of dexamethasone implant in healthy, fellow eyes of patients who received dexamethasone implant for retinal vein occlusion in the affected eyes

Poster Details

First Author: S.Kivanc TURKEY

Co Author(s):    B. Akova Budak   M. Ulusoy                          

Abstract Details



Purpose:

To evaluate the effects of intravitreal dexamethasone implant in fellow eyes with normal examination findings of patients who had retinal vein occlusion in the implanted eye.

Setting:

Uludag University Department of Ophthalmology, Bursa, Turkey

Methods:

Twenty-six fellow eyes of 26 patients with the diagnosis of retinal vein occlusion which underwent intravitreal dexamethasone implantation were included. The medical records of 26 patients (12 males, 14 females) with a mean age of 62.8±8.9 years and a minimum follow up of 6 months were reviewed. The OCT findings of fellow eyes as total macular volume (TMV), central macular volume (CMV), central macular thickness (CMT), subfovealchoroidal thickness (SCT), the choroidal thickness (CT) at 1.5 and 3 mm nasal and temporal to the fovea were measured before injection and after injection at 1st , 3rd and 6th months. Additionally, a new parameter as subfoveal cross-sectional choroidal area (SCCA) was calculated.

Results:

There was a significant difference between SCT values before injection (339±65µ) and after at 1st (318±61µ) and 3rd months(325±68µ) (p =0.003 and p= 0.019 respectively). CT at 3 mm nasal and temporal to fovea at 6 months (187±47µ and 257±76µ respectively) were significantly increased than before injection(175±48µ and 245±53µ; p=0.033 and p=0.001 respectively). SCCA was significantly decreased at 1st month (1.66±0.3mm2) compared to before injection(1.73±0.3 mm2; p=0.002). TMV was 8.43±0.5mm3 before injection decreased to 8.36±0.4mm3 at first month and increased to 8.52±0.5mm3 at 6th month. However the differences were not statistically significant. There were no significant differences between before injection and after injection values for CMV and CMT. No correlation was found between SCT and CT at 3 mm nasal and temporal to fovea. However, SCCA was significantly correlated with all parameters except CT at 3 mm nasal to fovea.

Conclusions:

This study suggests that Ozurdex® implantation may affect the fellow eye of patients with retinal vein occlusion. The findings at 1st month were significantly lower than before injection both for choroid and retina except foveal parameters. The increased values at 6 month suggest a rebound effect . Choroidal area measurement is successful in interpreting choroidal changes in general.

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